Differential expression of circulating microRNAs according to severity of colorectal neoplasia

Translational Research : the Journal of Laboratory and Clinical Medicine
Gloria Y F HoYousin Suh

Abstract

There is a need to develop a colorectal cancer (CRC) screening test that is noninvasive, cost effective, and sensitive enough to detect preneoplastic lesions. This case-control study examined the feasibility of using circulating extracellular microRNAs (miRNAs) to differentiate a spectrum of colorectal neoplasia of various severity and hence for early detection of colorectal neoplasia. Archived serum samples of 10 normal controls and 31 cases, including 10 with nonadvanced adenoma, 10 with advanced adenoma, and 11 with CRC, were profiled for circulating miRNAs using next-generation sequencing. Multiple linear regression, adjusting for age, gender, and smoking status, compared controls and the 3 case groups for levels of 175 miRNAs that met stringent criteria for miRNA sequencing analysis. Of the 175 miRNAs, 106 miRNAs were downregulated according to severity of neoplasia and showed a relative decrease in the expression from controls to nonadvanced adenoma to advanced adenoma to CRC (Ptrend < 0.05). Pairwise group comparisons showed that 39 and 80 miRNAs were differentially expressed in the advanced adenoma and CRC groups compared with the controls, respectively. Differences in miRNA levels between the nonadvanced adenoma group ...Continue Reading

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Citations

Aug 4, 2016·Carcinogenesis·Petra Vychytilova-FaltejskovaOndrej Slaby
Sep 1, 2016·Journal of Extracellular Vesicles·Marie Stampe OstenfeldClaus Lindbjerg Andersen
Mar 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hwa Jin JungYousin Suh
May 10, 2020·International Journal of Molecular Sciences·Anna SiskovaVeronika Vymetalkova
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