Differential expression of circulating miRNAs as a novel tool to assess BAG3-associated familial dilated cardiomyopathy

Bioscience Reports
Carlos ZaragozaRocio Toro

Abstract

A new familial dilated cardiomyopathy (FDCM) was found related to mutations in BAG3 gene. MicroRNAs (miRNAs) represent new targets of FDCM, although no studies have assessed clinical association between Bcl2-associated athanogene 3 (BAG3)-related DCM and miRNAs. Here, we studied whether a clinical association between BAG3-related FDCM and circulating miRNAs may have diagnostic and prognostic value in a small cohort of familial related individuals carrying a BAG3 mutation (BAG3+) and/or diagnosed of dilated cardiomyopathy (DCM) (DCM+). The analysis of 1759 circulating miRNAs showed significant differences between BAG3+ and BAG3- individuals for miRNAs mir-3191-3p, 6769b-3p, 1249-ep, 154-5p, 6855-5p, and 182-5p, while comparisons between BAG3+/DCM+ versus BAG3+/DCM- were restricted to miRNAs mir-154-5p, 6885-5p, and 182-5p, showing significant correlation with systolic and diastolic blood pressure, A wave, left atrium length, and left atrium area. Additionally, when stratified by gender and age, miRNAs were statistically correlated with critical parameters, including left ventricle ejection fraction (LVEF) and ventricular diameter, in women and young men. Likewise, 56% of BAG3+/DCM+, significantly co-expressed mir-154-5p and mir-...Continue Reading

References

Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·Shigeo MurataKeiji Tanaka
Nov 2, 2004·Statistical Methods in Medical Research·Brian Everitt
Feb 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jian-Fu ChenDa-Zhi Wang
Mar 4, 2010·Genome Biology·Mark D Robinson, Alicia Oshlack
Jan 21, 2011·Nature·Eric M Small, Eric N Olson
Mar 4, 2014·Journal of the American College of Cardiology·Gianluigi CondorelliElena Cavarretta
Apr 20, 2014·The Journal of Clinical Investigation·Claudia BangThomas Thum
Jun 14, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Begoña LavinCarlos Zaragoza
Sep 10, 2014·Nature Reviews. Cardiology·Thomas Thum
Dec 3, 2014·The Canadian Journal of Cardiology·Nathalie ChamiGuillaume Lettre
Dec 17, 2014·Nature Reviews. Cardiology·Reinier A Boon, Stefanie Dimmeler
Feb 3, 2015·Journal of Cardiovascular Medicine·Huseyin Altug CakmakVural Ali Vural
Mar 31, 2015·Heart·Simon P R RomaineNilesh J Samani
May 1, 2015·Heart Failure Reviews·Tijana KnezevicArthur M Feldman
Jan 23, 2016·Journal of Molecular and Cellular Cardiology·Arthur M FeldmanJoseph Y Cheung
May 18, 2016·Nucleic Acids Research·Sasha BabickiDavid S Wishart
Jul 8, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jiankai ZhangXiaojun Cui
Nov 3, 2016·Cardiology Journal·Hua WangJiefu Yang
Feb 1, 2017·JCI Insight·Carmen C SucharovMichael R Bristow
Jul 25, 2017·The Journal of Clinical Investigation·Xi FangJu Chen

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Citations

Oct 15, 2020·Revista Española De Cardiología·Maria Calderon-DominguezRocío Toro
Mar 31, 2021·Revista Española De Cardiología·Sandra Sánchez-EstebanMarta Saura
Apr 8, 2021·Scientific Reports·Maria Calderon-DominguezRocio Toro
May 22, 2021·Journal of the American College of Cardiology·Diane FatkinJason C Kovacic
Jun 3, 2021·International Journal of Molecular Sciences·Larisa AnghelCristian Stătescu

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Methods Mentioned

BETA
PCR

Software Mentioned

Bioconductor package
edgeR

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