Differential expression of cyclooxygenase-2 and cyclin D1 in salivary gland tumors

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Jefferson da Rocha TenórioAna Paula Veras Sobral

Abstract

Salivary gland tumors are complex and have a great histomorphological diversity; more than 30 histological subtypes are currently described and the study of proteins that help understand and differentiate these tumors is essential. We aimed to analyze the immunoexpression of cyclooxygenase-2 (COX-2) and cyclin D1 proteins in pleomorphic adenomas (PA), mucoepidermoid carcinomas (MEC) and adenoid cystic carcinomas (AdCC) of salivary glands. A total of 38 PA, 12 AdCC and 12 MEC underwent immunohistochemical study by the polymeric biotin-free technique. Immunopositive cells were analyzed semi-quantitatively. For statistical analysis, a significance level was set at p ≤ 0.05. Overall, these tumors were more prevalent in women (n = 37). The mean age of these patients was 58-year-old and the parotid gland was the most affected anatomic site (n = 33). All cases of AdCC and MEC showed immunopositivity to cyclin D1; however, 39.5% of the PAs were negative (p < 0.001). Regarding COX-2 immunoexpression, we observed that all cases of CME were positive, whereas 60.5% of the PA and 75% of the CAC analyzed were completely negative (p = 0.042). The overexpression of COX-2, observed only in MEC, emphasizes that salivary gland tumors have differe...Continue Reading

References

Apr 24, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Nam-Pyo ChoHyun-Jin Son
Apr 17, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·H Mehmet TurkMustafa Adli
Oct 31, 2012·Korean Journal of Pathology·Ji Won LeeKyung Chul Moon
Jul 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Di WangChun-Yan Wu
Jul 22, 2015·Journal of Mammary Gland Biology and Neoplasia·Honor J HugoE W Thompson
Oct 23, 2016·International Journal of Oral and Maxillofacial Surgery·M GaoG Y Yu
Nov 5, 2016·Clinical Colorectal Cancer·Yongsong LiuYingting Zhu
Jun 15, 2017·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Reena Rachel JohnSoumya Anandan

❮ Previous
Next ❯

Citations

Dec 9, 2020·International Journal of Molecular Sciences·Ellen FrejborgAbdelhakim Salem

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.

Related Papers

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Leorik Pereira SilvaMárcia Cristina da Costa Miguel
Shanghai kou qiang yi xue = Shanghai journal of stomatology
Zhao-rong NingDian-ji Fang
European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Leorik Pereira SilvaLélia Batista de Souza
European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Lélia Batista de SouzaLélia Maria Guedes Queiroz
© 2022 Meta ULC. All rights reserved