Abstract
Salivary gland tumors are complex and have a great histomorphological diversity; more than 30 histological subtypes are currently described and the study of proteins that help understand and differentiate these tumors is essential. We aimed to analyze the immunoexpression of cyclooxygenase-2 (COX-2) and cyclin D1 proteins in pleomorphic adenomas (PA), mucoepidermoid carcinomas (MEC) and adenoid cystic carcinomas (AdCC) of salivary glands. A total of 38 PA, 12 AdCC and 12 MEC underwent immunohistochemical study by the polymeric biotin-free technique. Immunopositive cells were analyzed semi-quantitatively. For statistical analysis, a significance level was set at p ≤ 0.05. Overall, these tumors were more prevalent in women (n = 37). The mean age of these patients was 58-year-old and the parotid gland was the most affected anatomic site (n = 33). All cases of AdCC and MEC showed immunopositivity to cyclin D1; however, 39.5% of the PAs were negative (p < 0.001). Regarding COX-2 immunoexpression, we observed that all cases of CME were positive, whereas 60.5% of the PA and 75% of the CAC analyzed were completely negative (p = 0.042). The overexpression of COX-2, observed only in MEC, emphasizes that salivary gland tumors have differe...Continue Reading
References
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shishir ShishodiaBharat B Aggarwal
Apr 24, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Nam-Pyo ChoHyun-Jin Son
Oct 12, 2007·Histopathology·R S PatelC J O'Brien
Sep 5, 2009·Oral Oncology·Sharon AkrishRafi M Nagler
Dec 3, 2009·International Journal of Oral and Maxillofacial Surgery·Z TianJ Li
Apr 14, 2011·Yonsei Medical Journal·Seoung Wan ChaeJun Ho Kim
Jul 29, 2011·Cell Death & Disease·B LiuM Han
Apr 17, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·H Mehmet TurkMustafa Adli
Oct 31, 2012·Korean Journal of Pathology·Ji Won LeeKyung Chul Moon
Jan 15, 2013·Head and Neck Pathology·G JourB M Wenig
Nov 2, 2013·Digestive Diseases and Sciences·Jian SongLiang-Liang Guo
Jul 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Di WangChun-Yan Wu
Jul 22, 2015·Journal of Mammary Gland Biology and Neoplasia·Honor J HugoE W Thompson
Jan 2, 2016·Oncology Letters·Eun-Young LeeKyoung-Won Kim
Jul 9, 2016·Melanoma Research·Łukasz KuźbickiBarbara W Chwirot
Oct 23, 2016·International Journal of Oral and Maxillofacial Surgery·M GaoG Y Yu
Nov 5, 2016·Clinical Colorectal Cancer·Yongsong LiuYingting Zhu
Nov 7, 2016·Medical Oncology·Monica Charlotte SolomonChetana Chandrashekar
Nov 25, 2016·Stem Cells International·Lisa Y PangDavid J Argyle
Dec 22, 2016·Oncotarget·Feng XuHongchuan Jiang
Jan 21, 2017·Oncotarget·Bhavna KumarPawan Kumar
Feb 10, 2017·Cell Death & Disease·Kai QuChang Liu
Mar 2, 2017·Head and Neck Pathology·Raja R Seethala, Göran Stenman
Mar 3, 2017·Oral Oncology·M H ValstarL E Smeele
Mar 17, 2017·PloS One·Gui YangMingxia Yu
Jun 15, 2017·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Reena Rachel JohnSoumya Anandan
Jun 20, 2017·Oncogene·J JenY-C Wang