Differential expression of E-cadherin and P-cadherin in pT3 prostate cancer: correlation with clinical and pathological features

Virchows Archiv : an International Journal of Pathology
Catarina FerreiraRui Henrique

Abstract

Cadherins seem to play and important role in prostate cancer (PCa) progression. E-cadherin loss of expression has been associated with poor prognosis; P-cadherin's role is still elusive. Although pT3 PCa is often considered "high-risk cancer," it does not exhibit an uniformly poor prognosis. Herein, we assessed the prognostic value and survival impact of E-cadherin and P-cadherin immunoexpression in pT3 PCa. Radical prostatectomy (RP) specimens from 102 pT3 PCa patients treated between 1991 and 2014 in a single institution were designated for E-cadherin and P-cadherin immunoexpression analysis. A representative block from each specimen was selected for tissue micro-array (TMA) construction, using 3 cores per case. E-cadherin immunoexpression was assessed via a digital image analysis system. For P-cadherin, scoring criteria for HER2 in gastric cancer were used. Clinical records of all patients were reviewed for baseline clinical/pathologic characteristics and follow-up data. E-cadherin-low PCa patients displayed worse disease-specific survival (DSS), although not reaching statistical significance (HR 2.65, 95%CI 0.81-7.88). However, considering the pT3b group only, those with low E-cadherin immunoexpression displayed significant...Continue Reading

References

Jun 1, 1990·British Journal of Urology·J AdolfssonP O Hedlund
Aug 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S LoricP Eschwège
Oct 9, 2001·Epidemiologic Reviews·G J Miller, K C Torkko
Jan 15, 2002·Virchows Archiv : an International Journal of Pathology·E Van AkenM Mareel
Jul 4, 2002·Journal of the National Cancer Institute·Ruth EtzioniEric J Feuer
Jun 10, 2004·JAMA : the Journal of the American Medical Association·Jan-Erik JohanssonHans-Olov Adami
Oct 24, 2007·European Urology·Hendrik Van Poppel, Steven Joniau
Nov 16, 2007·Breast Cancer Research : BCR·Joana ParedesFernando C Schmitt
Dec 7, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karsten GravdalLars A Akslen
May 17, 2008·Cancer Research·Tamer T OnderRobert A Weinberg
Aug 8, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jose PontesKatia R M Leite
Sep 17, 2008·Molecular and Cellular Biology·Yan-Nian LiuJi-Hshiung Chen
Oct 14, 2008·The International Journal of Biochemistry & Cell Biology·Paco Hulpiau, Frans van Roy
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katsunori ImaiYasuharu Nishimura
May 28, 2009·Virchows Archiv : an International Journal of Pathology·Marc MareelIndira Madani
Nov 17, 2009·Cancer Investigation·Nektaria MakriliaKostas Syrigos
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Jan 29, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yasuto UchikadoShoji Natsugoe
Dec 14, 2011·The International Journal of Developmental Biology·André AlbergariaJoana Paredes
May 23, 2012·Biochimica Et Biophysica Acta·Joana ParedesRaquel Seruca
Jan 25, 2013·Nature Reviews. Cancer·Bram De Craene, Geert Berx
Aug 13, 2013·Experimental and Molecular Pathology·Helen WhitelandShareen H Doak
Dec 11, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Dec 9, 2014·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Igor TsaurRoman A Blaheta
Jun 16, 2015·Lancet·Gerhardt AttardJohann S de Bono
Jul 15, 2015·European Urology·Jonathan I EpsteinEric A Klein
Oct 7, 2015·Molecular Cancer·André Filipe Vieira, Joana Paredes
Dec 15, 2015·Urologic Oncology·Alexandros DrivalosAristotelis Bamias
Feb 18, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Qiu-Kui DengWen-Ping Li
Apr 22, 2016·British Journal of Cancer·Daniel M BerneyJack Cuzick
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Aug 24, 2017·Türk patoloji dergisi·Aziza E AbdelrahmanRagab A Ahmed

❮ Previous
Next ❯

Citations

Jun 25, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·João LoboRui Henrique

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.