PMID: 7521375Sep 1, 1994Paper

Differential expression of genes encoding a cysteine-rich keratin family in the hair cuticle

The Journal of Investigative Dermatology
B J Jenkins, B C Powell

Abstract

In the hair follicle the cuticle develops as a thin layer of cells between the hair shaft cortex and the inner root sheath. Once the cuticle cells begin to differentiate they accumulate cysteine-rich granules in their cytoplasm but the identity of their constituent proteins has remained largely an enigma. In this report we show differential expression of a family of genes encoding cysteine-rich, glycine-rich keratins in the cuticle. Two clones of the sheep KAP5 gene family were isolated: the KAP5.4 cDNA encodes a protein of 190 amino acids (M(r) = 16,936) containing 32 mol% cysteine, 26 mol% glycine and the partial KAP5.5 cDNA encodes a protein of at least 197 amino acids (M(r) > or = 17,474) containing 29 mol% cysteine, 28 mol% glycine. The predicted amino acid sequences of the KAP5 family show extensive sequence conservation and all the proteins are composed almost entirely of cysteine-rich and glycine-rich repeats. Each KAP5 gene produces an approximately 1.5-kb mRNA species but the KAP5.4 and KAP5.5 mRNA levels appear to be severalfold greater than the KAP5.1 mRNA. Comparative tissue in situ hybridizations reveal a positive correlation between the onset of expression and follicle depth. For a given KAP5 gene two widely diff...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1992·DNA Sequence : the Journal of DNA Sequencing and Mapping·B J Jenkins, B C Powell
Mar 1, 1990·The Journal of Investigative Dermatology·A P BertolinoD W Yu
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·P J MacKinnonG R Sutherland
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Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
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Feb 1, 1994·The Journal of Investigative Dermatology·A FratiniG E Rogers

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Citations

Sep 14, 2002·The Journal of Biological Chemistry·Yutaka ShimomuraMasaaki Ito
Dec 12, 2019·Proceedings. Mathematical, Physical, and Engineering Sciences·Elsabe CloeteMalebogo N Ngoepe
May 31, 2016·Genes·Hua GongJon G H Hickford
Jan 8, 2021·Journal of Applied Genetics·Agnieszka NiedzielaPiotr Tomasz Bednarek
Jun 13, 1996·Biochimica Et Biophysica Acta·K KizawaU Murakami
Nov 6, 1998·The Journal of Investigative Dermatology·K KizawaH Uchiwa
Feb 14, 2002·The Journal of Investigative Dermatology·Yutaka ShimomuraMasaaki Ito
Aug 5, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Yutaka ShimomuraMasaaki Ito
Mar 11, 2009·Differentiation; Research in Biological Diversity·Zhidong YuAllan J Pearson

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