PMID: 11315192Apr 21, 2001Paper

Differential expression of genes for uncoupling proteins 1, 2 and 3 in brown and white adipose tissue depots during rat development

Cellular and Molecular Life Sciences : CMLS
Paula OliverAndreu Palou

Abstract

The different expression patterns of genes for uncoupling proteins (UCPs) 1, 2 and 3 (ucp1, ucp2 and ucp3) were studied in interscapular brown adipose tissue (BAT) and in four white adipose tissue (WAT) depots (epididymal, inguinal, mesenteric and retroperitoneal) in male rats of different ages (18 days-12 months). UCP mRNA expression levels were determined by Northern blotting. In BAT, there were high levels of expression of UCP1 and UCP3 mRNA, but no detectable levels of UCP2 mRNA. Both ucp1 and ucp3 followed a similar expression pattern with age, with high levels in suckling rats which decreased to 50% or less in rats just under 2 months old, declining thereafter until 5 months and then recovering with age. However, an additional peak of expression was observed for ucp3 at the age of 3 months. In WAT, ucp1 expression was rare: occasional expression was found for UCP1 mRNA in the retroperitoneal depot in suckling rats and in the epididymal and inguinal depots in suckling and mature adult rats. ucp2 and ucp3 had different developmental expression patterns, but these were similar for each gene in the different depots studied. UCP3 mRNA was highly expressed in rats soon after birth, it decreased until 3 months, and increased the...Continue Reading

Citations

Feb 24, 2012·Journal of Applied Genetics·Ya-Nan YuanJian-Liang Wu
May 21, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A CaimariA Palou
Oct 6, 2012·The Journal of Toxicological Sciences·Young-Man ChoAkiyoshi Nishikawa
Oct 13, 2007·Molecular and Cellular Endocrinology·Theodora TzanavariPaul Trayhurn
Jul 31, 2018·Asian-Australasian Journal of Animal Sciences·Ruiyi LinTianfang Xiao
Oct 9, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Andreu PalouMaria Luisa Bonet
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Dec 8, 2020·Frontiers in Cardiovascular Medicine·Ibrahim AlZaimAhmed F El-Yazbi

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