Abstract
In this study, we examined the expression of glypican-3 (GPC3) in the 2 most common histological types of lung cancer, squamous cell carcinoma and adenocarcinoma, and explored the relationship between GPC3 expression and the prognosis of these 2 types of lung cancers. Lung cancer tissues and paracancerous tissues were collected from a total of 60 patients with lung squamous cell carcinoma or lung adenocarcinoma. GPC3 gene and protein expression in the tissue samples was examined using fluorescence-based real-time quantitative polymerase chain reaction, immunohistochemistry, and western blot analysis. In addition, the serological levels of GPC3 protein in lung cancer patients were analyzed using enzyme-linked immunosorbent assays. The overall expression of GPC3 protein in lung cancer was 45% (21/60). No GPC3 expression was detected in paracancerous lung tissues. Positive expression of GPC3 protein in lung squamous cell carcinoma was significantly higher than that in lung adenocarcinoma (70 vs 20%, P < 0.001). Among GPC3-positive lung squamous cell carcinoma and lung adenocarcinoma samples, samples collected from patients with lymph node metastasis and patients with poorly differentiated cancer exhibited more pronounced GPC-3 exp...Continue Reading
Citations
Oct 23, 2016·BMC Cancer·Lei ShiYong Teng
Jun 5, 2019·Bioscience Reports·Dongchang WangGang Chen
Oct 20, 2018·Postgraduate Medical Journal·Shui-Ping DaiWei-Min Li
Dec 7, 2017·Oncotarget·Mengyin WuYueping Shen
Aug 31, 2017·Archives of Pathology & Laboratory Medicine·Hanlin L WangFan Lin
Jan 19, 2017·Oncology Reports·Mauro MontalbanoLuca Cicalese
Mar 21, 2020·Signal Transduction and Targeted Therapy·Jawad FaresYoussef Fares
Jun 25, 2020·Biomolecules·Bryan D Fleming, Mitchell Ho
Jul 9, 2020·Archives of Dermatological Research·Abdullah Alyoussef
Dec 31, 2020·Journal of Hepatocellular Carcinoma·Jingjing ZongYewei Zhang
Nov 21, 2020·Investigational New Drugs·Lin YuLiangpeng Ge
Apr 17, 2020·Signal Transduction and Targeted Therapy·Jawad FaresYoussef Fares
Jun 12, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Jia LeiYi Zhang
Sep 12, 2018·Chemical Reviews·Nikos K KaramanosRenato V Iozzo
Jun 7, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Kiran JotPriya Kumar