PMID: 15249855Jul 14, 2004Paper

Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity

The American Journal of Dermatopathology
Ning LiGiovanni Tallini

Abstract

The histologic distinction of dermatofibrosarcoma protuberans (DFSP) and dermatofibroma (DF) may be difficult, especially in the case of DF extending into the subcutaneous fat (deep DF). CD34 and Factor XIIIa staining is commonly used in separating DF from DFSP, but is not always helpful. HMGA1 and HMGA2 genes, members of the high mobility group protein family genes, encode proteins that act as architectural transcription factors and are frequently dysregulated in a variety of benign or locally aggressive mesenchymal tumors. In this study, we evaluated the immunoreactivity of HMGA1 and HMGA2 in a series of DF and DFSP to determine the possible utility for these markers in the differential diagnosis of these two entities. Immunohistochemical stains were performed on paraffin-embedded tissues from 22 cases of DF, including 14 cases of deep DF and 14 cases of DFSP, using antibodies against HMGA1 and HMGA2. CD34 and Factor XIIIa immunoreactivity was also evaluated in these lesions and compared with the results of HMGA immunostaining. Immunopositivity for both HMGA1 and HMGA2 was seen in 21of 22 (96%) DFs, but in only 3 (21%) and 1 (7%) of 14 DFSPs, respectively. While 100% of DFSP stained for CD34, 36% of DF also labeled for CD34. ...Continue Reading

References

Dec 1, 1990·The American Journal of Surgical Pathology·H Kamino, M Jacobson
Oct 1, 1994·The American Journal of Dermatopathology·P R CohenA I Farhood
Oct 1, 1993·The American Journal of Dermatopathology·P Abenoza, T Lillemoe
Jan 1, 1996·Anatomy and Embryology·N S GibranK A Holbrook
Nov 21, 1998·Genes, Chromosomes & Cancer·U Hirning-FolzH Hameister
Jul 9, 1999·Genes, Chromosomes & Cancer·G J GattasC C Morton
Sep 3, 1999·Advances in Anatomic Pathology·G Tallini, P Dal Cin
Feb 5, 2000·Journal of Cutaneous Pathology·T C ChenH L Chan
Feb 25, 2000·Cancer Genetics and Cytogenetics·B KazmierczakJ Bullerdiek
Apr 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·K BrobergF Mertens
Feb 28, 2002·Journal of the American Academy of Dermatology·Bernard CribierEdouard Grosshans
Jul 26, 2002·Journal of Cutaneous Pathology·Pei HuiArchibald S Perkins
Sep 26, 2002·Archives of Pathology & Laboratory Medicine·Andrea K Bruecks, Martin J Trotter
Mar 19, 2003·Journal of Cutaneous Pathology·Emel CalikogluGürkan Kaya

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Citations

Sep 14, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nadège DreuxJean-Michel Coindre
Jul 21, 2010·The American Journal of Dermatopathology·Anna Maria CesinaroAntonio Maiorana
Dec 22, 2009·Future Oncology·Mai P HoangM Angelica Selim
Nov 21, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Maya K ThosaniChih-Shan Jason Chen
Oct 24, 2012·The Kaohsiung Journal of Medical Sciences·Yi-Ting ChenChee-Yin Chai
Jan 19, 2013·Seminars in Diagnostic Pathology·Beatriz LlombartOnofre Sanmartín
Jan 19, 2008·Journal of Cutaneous Pathology·Neta AdlerMeora Feinmesser
Aug 19, 2008·The Journal of Dermatology·Toru MoriYutaka Narisawa
Aug 8, 2009·The British Journal of Dermatology·K SellheyerD Krahl
Dec 31, 2014·Archives of Pathology & Laboratory Medicine·Tammie Ferringer
Aug 21, 2016·The Surgical Clinics of North America·Jeffrey Reha, Steven C Katz
Jan 8, 2019·Journal of Cellular and Molecular Medicine·Yuhong WangLingchuan Guo
Jun 27, 2006·International Journal of Dermatology·Kirk H Waibel, Douglas S Walsh
Oct 29, 2013·The American Journal of Dermatopathology·Kelly L WestPuja K Puri
Nov 20, 2013·The American Journal of Dermatopathology·Viktoryia KazlouskayaDirk M Elston
Jul 12, 2017·Oncology Letters·Kamil PohlodekZdeněk Kinkor
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Josefine Heim-Hall, Sophia L Yohe
Jul 21, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Hansini LaharwaniIsrah Akhtar

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