Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia.

Virology Journal
Satoshi BabaKei Kawana

Abstract

Human papillomavirus (HPV) infection is a primary cause of cervical cancer. Although epidemiologic study revealed that carcinogenic risk differs according to HPV genotypes, the expression patterns of HPV-derived transcripts and their dependence on HPV genotypes have not yet been fully elucidated. In this study, 382 patients with abnormal cervical cytology were enrolled to assess the associations between HPV-derived transcripts and cervical intraepithelial neoplasia (CIN) grades and/or HPV genotypes. Specifically, four HPV-derived transcripts, namely, oncogenes E6 and E6*, E1^E4, and viral capsid protein L1 in four major HPV genotypes-HPV 16, 18, 52, and 58-were investigated. The detection rate of E6/E6* increased with CIN progression, whereas there was no significant change in the detection rate of E1^E4 or L1 among CIN grades. In addition, we found that L1 gene expression was HPV type-dependent. Almost all HPV 52-positive specimens, approximately 50% of HPV 58-positive specimens, around 33% of HPV 16-positive specimens, and only one HPV18-positive specimen expressed L1. We demonstrated that HPV-derived transcripts are HPV genotype-dependent. Especially, expression patterns of L1 gene expression might reflect HPV genotype-depen...Continue Reading

References

Feb 7, 2003·The New England Journal of Medicine·Nubia MuñozUNKNOWN International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
May 25, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Zhi-Ming Zheng, Carl C Baker
Jul 14, 2007·Disease Markers·Anna-Barbara Moscicki
Sep 11, 2007·Lancet·Mark SchiffmanSholom Wacholder
Dec 5, 2009·International Journal of Cancer. Journal International Du Cancer·Chih-Ming HoWen-Fang Cheng
Feb 6, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Young Sam ChoiHo Sun Choi
Jan 24, 2017·Nature·UNKNOWN Cancer Genome Atlas Research NetworkUNKNOWN Washington University in St Louis
May 23, 2017·Mutation Research. Reviews in Mutation Research·Suruchi Mittal, Lawrence Banks

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Methods Mentioned

BETA
biopsy
genotyping
PCR

Software Mentioned

Primer
JMP Pro
- Blast

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