PMID: 7521903Sep 1, 1994Paper

Differential expression of ICAM-1, VCAM-1 and their ligands LFA-1, Mac-1, CD43, VLA-4, and MHC class II antigens in murine Toxoplasma encephalitis: a light microscopic and ultrastructural immunohistochemical study

Journal of Neuropathology and Experimental Neurology
M Deckert-SchlüterH Lassmann

Abstract

Light microscopic and ultrastructural immunohistochemistry of cell adhesion molecules (CAMs) and major histocompatibility class II antigens (Ia) expression in experimental murine Toxoplasma encephalitis (TE) revealed a prominent upregulation of the intercellular cell adhesion molecule-1 (ICAM-1) and of Ia on cerebral endothelia, microglia, ependyma, and choroid plexus epithelium during acute and chronic TE. Microglia also expressed Mac-1 and leukocyte function-associated antigen-1 (LFA-1), which are both ligands of ICAM-1, as well as CD45. The prominent simultaneous expression of a multitude of these molecules on microglia is indicative of a central immunologic function of this cell type in TE. Additionally, occasional astrocytic processes slightly expressed Ia in full-blown TE. The vascular cell adhesion molecule-1 (VCAM-1) was restricted to endothelia of cerebral blood vessels, which frequently showed perivascular cuffing of inflammatory cells, ependyma, and choroid plexus epithelium. Upregulation of Ia, CAMs and their ligands correlated with disease activity. Immunohistochemical analysis of the functional state of infiltrating T cells showed a preferential recruitment of CD44+ memory and activated interleukin-2R+ T cells in TE.

Citations

Apr 29, 1998·Microscopy Research and Technique·J E Bruni
Jan 3, 2001·Microscopy Research and Technique·B EngelhardtH Wolburg
Aug 1, 1994·Journal of Neuroimmunology·M Deckert-SchlüterH Hof
Apr 6, 2004·International Journal for Parasitology·Emma H Wilson, Christopher A Hunter
Dec 31, 1997·Journal of the Neurological Sciences·A YamamotoT Kobayashi
May 5, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xisheng WangYasuhiro Suzuki
Jun 2, 2011·Infection and Immunity·Isabel Dellacasa-LindbergAntonio Barragan
May 5, 2010·The Journal of Clinical Investigation·Emma H WilsonChristopher A Hunter
May 7, 2014·Journal of Visualized Experiments : JoVE·Matteo DonegàStefano Pluchino
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Pia KivisäkkRichard M Ransohoff
Jun 1, 1997·Journal of Neuroimmunology·M Deckert-SchlüterD Schlüter
Jan 16, 2013·Molecular Pharmaceutics·Mikhail I PapisovKimberley S Gannon
Apr 27, 2005·Brain Research. Brain Research Reviews·Stefano PluchinoGianvito Martino
Feb 28, 2006·International Journal for Parasitology·Carlos HermosillaAnja Taubert
Jul 26, 2005·Trends in Immunology·Britta Engelhardt, Richard M Ransohoff
Jul 22, 2014·Tissue Barriers·Antonio J JiménezJosé-Manuel Pérez-Fígares
Mar 1, 2011·European Journal of Microbiology & Immunology·L M Randall, C A Hunter
Apr 23, 2015·Seminars in Immunopathology·Tyler A LandrithEmma H Wilson
Aug 21, 2012·Cell Adhesion & Migration·Rick B MeekerLola C Hudson
Mar 31, 2012·Virulence·Sabrina M FeustelOliver Liesenfeld
Mar 31, 2012·Virulence·Willias Masocha, Krister Kristensson
Sep 25, 2008·Revista Do Instituto De Medicina Tropical De São Paulo·Karen Regina LemosRosangela Zacarias Zacarias
May 29, 2004·Current Opinion in Neurology·Stefano PluchinoGianvito Martino
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lai-Yu KwokDirk Schlüter
Apr 1, 2008·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Karen R LemosRozângela Z Machado
Oct 27, 2017·American Journal of Physiology. Cell Physiology·Alexa N LauerChristian Schwerk
Nov 30, 2019·Pediatric Neurology·Grant A Dixon, Carlos A Pérez

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