Differential expression of IEG mRNA in rat brain following acute treatment with clozapine or haloperidol: a semi-quantitative RT-PCR study

Journal of Psychopharmacology
M J RobbinsP R Maycox

Abstract

Antipsychotic drugs have been shown to modulate immediate early gene (IEG) expression in rat brain regions that are associated with schizophrenia, which may be directly linked to their immediate therapeutic benefit. In this study, we analysed the expression profile of a series of IEGs (c-fos, c-jun, fra-1, Krox-20, Krox-24, arc, sgk-1, BDNF and NARP) in six rat brain regions (prefrontal cortex, hippocampus, striatum, nucleus accumbens, thalamus and cerebellum). Rats (n=5) were administered either clozapine (20 mg/kg i.p.), haloperidol (1 mg/kg i.p.) or the appropriate vehicle with pre-treatment times of 1, 6 and 24 h. IEG expression was analysed in these regions by Taqman RT-PCR. The spatial and temporal profile of IEG induction following antipsychotic drug treatment correlates with regions associated with the efficacy and side effect profile of each drug. In particular, sgk-1 expression levels after antipsychotic drug treatment may have predictive value when investigating the profile of a novel antipsychotic drug.

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Citations

Jan 20, 2011·Bulletin of Experimental Biology and Medicine·S A KryzhanovskyiS B Seredenin
May 13, 2014·Journal of Neural Transmission·Susanna WatersNicholas Waters
Jun 10, 2010·The Journal of Physiology·Florian LangUndine E Lang
Oct 25, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Fabio FumagalliMarco Andrea Riva
Mar 17, 2016·Neuroscience·Alicia IzquierdoAndrew Holmes
Feb 5, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andrea de BartolomeisCarmine Tomasetti
Mar 23, 2017·Frontiers in Behavioral Neuroscience·Florian Duclot, Mohamed Kabbaj
Aug 8, 2018·Genes, Brain, and Behavior·Magdalena ZygmuntMichał Korostyński
May 15, 2018·Frontiers in Behavioral Neuroscience·Francisco T GalloNoelia V Weisstaub

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