PMID: 9161641Apr 1, 1997Paper

Differential expression of IGF-I and IGF-II in eutopic and ectopic endometria of women with endometriosis and in women without endometriosis

American Journal of Reproductive Immunology : AJRI
M SbraciaC Romanini

Abstract

Factors regulating the development, growth, and differentiation of endometrial cells of endometriotic lesions are poorly understood. To investigate the paracrine-autocrine regulation of ectopic endometrial cell growth, the expression of IGF-I and IGF-II were studied. Tissue specimens of eutopic and ectopic endometria were obtained from eight patients with endometriosis at laparoscopy and from the endometria of 14 women without endometriosis as controls. They were tested for the expression of IGF-I and IGF-II by immunohistochemical analysis. Immunohistochemical study for IGF-I in controls showed a more intense staining during the proliferative phase both in stromal and epithelial cells. In eutopic endometria of women with endometriosis a reduction in the staining was observed, whereas in epithelial cells of fibrotic peritoneal adhesions an intense immunostaining for IGF-I was observed. Immunohistochemical study of IGF-II in controls showed a more intense staining during secretory phase both in stromal and epithelial cells. In eutopic endometria of women with endometriosis, a reduction in the staining was observed, whereas in epithelial cells of fibrotic peritoneal adhesions an intense immunostaining for IGF-I was observed. Immun...Continue Reading

Citations

Apr 17, 2002·Maturitas·R Druckmann, U D Rohr
Aug 4, 2001·The American Journal of Pathology·E ParrottP Greaves
Jan 16, 2015·Biology of Reproduction·Laila F Jerman, Alison J Hey-Cunningham
Apr 21, 2016·The Cochrane Database of Systematic Reviews·Devashana GuptaVicki Nisenblat
Jan 30, 2004·American Journal of Reproductive Immunology : AJRI·Ann-Muriel SteffDiane Gosselin
Nov 18, 1998·Current Opinion in Obstetrics & Gynecology·D P Braun, W P Dmowski

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