Differential expression of inhibitory or activating CD94/NKG2 subtypes on MART-1-reactive T cells in vitiligo versus melanoma: a case report

The Journal of Investigative Dermatology
Lars Østergaard PedersenJürgen C Becker

Abstract

Selection and activation of T cells is tightly regulated by both antigen-specific receptors and co-receptors to ensure that responses to self antigens are largely avoided. By T cell receptor clonotypic mapping and staining with tetrameric HLA-peptide complexes, we demonstrate the presence of melanocyte differentiation antigen MART-1 specific T cells in the areas of destruction of both neoplastic and normal melanocytic cells in a case of a primary melanoma and its associated hypopigmentation. These self reactive T cells expressed CD94/NKG2 major histocompatibility complex class I specific C-type lectin-like receptors. This family of receptors includes both activating and inhibitory isoforms. Thus, we performed a detailed analysis that revealed the exclusive presence of inhibitory NKG2-A/B receptors in the vitiligo-like leukoderma, whereas both the inhibitory receptors and the activating NKG2-C/E isoforms were present within the tumor. Our data suggest the differential expression of killer inhibitory receptors as a possible mechanism to regulate T cell responses to self antigens.

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Citations

May 3, 2005·Nature Reviews. Drug Discovery·Mads Hald AndersenPer thor Straten
Sep 14, 2004·BMC Cancer·Joachim FensterleUlf R Rapp
Jan 19, 2006·The Journal of Investigative Dermatology·Mads Hald AndersenJürgen C Becker
Jul 16, 2003·Pigment Cell Research·Yvon GauthierAlain Taïeb
Aug 10, 2006·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander H EnkGerold Schuler
Oct 24, 2009·Experimental Dermatology·Jürgen C BeckerRalph A Reisfeld
Feb 18, 2006·Cancer Immunology, Immunotherapy : CII·Rafael SolanaRaquel Tarazona
May 13, 2005·Cancer Immunology, Immunotherapy : CII·Javier G CasadoRaquel Tarazona
May 16, 2008·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Anke HartmannEva-Bettina Bröcker

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