PMID: 7514848Jul 1, 1994Paper

Differential expression of interleukin-2 receptors (alpha and beta chain) in mature lymphoid neoplasms

American Journal of Hematology
K NakaseM Tsudo

Abstract

We investigated the expression of interleukin-2 receptors (IL-2R) in 60 adult patients with mature lymphoid neoplasms by flow cytometric analysis, using two monoclonal antibodies, anti-Tac for IL-2R alpha-chain (IL-2R alpha) and Mik-beta 1 for IL-2R beta-chain (IL-2R beta). Among B-cell malignancies, IL-2R alpha was found in 13/25 (52%) cases of chronic lymphocytic leukemia (CLL) and its variants, 3/14 (21%) of a heterogeneous group of non-Hodgkin's lymphoma (NHL) and none of the plasma cell diseases. IL-2R beta was not observed in any of B-cell neoplasms. IL-2R alpha was more frequently expressed in CD11b(+) B-cell neoplasms than in CD11b(-) (P < 0.05). In T-cell disorders, all three cases of adult T-cell leukemia/lymphoma expressed IL-2R alpha but not IL-2R beta. IL-2R beta was detected in 3/8 cases of CLL and 2/3 of NHL and none of these cases expressed IL-2R alpha. CD8(+) malignant T-cells commonly displayed IL-2R beta. These data indicate that the IL-2R alpha and IL-2R beta in mature lymphoid neoplasms was expressed independently each other and was associated with the particular phenotypical characteristics of neoplastic cells, respectively.

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Citations

Jun 10, 2011·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C-D Klemke
Feb 9, 2012·Current Treatment Options in Oncology·Tara BloomSteven T Rosen
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Apr 30, 2003·Expert Opinion on Biological Therapy·Arthur E FrankelRonald Gartenhaus
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Sep 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nam H DangLuis Fayad
Mar 7, 2006·Seminars in Oncology·Francine Foss
May 12, 2006·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Claus-Detlev KlemkeJürgen C Becker
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