PMID: 2113273Jun 11, 1990Paper

Differential expression of jun and fos genes during differentiation of mouse P19 embryonal carcinoma cells

Nucleic Acids Research
R P de GrootW Kruijer

Abstract

The jun and fos gene families encode DNA binding proteins involved in transcriptional regulation of genes containing a TPA responsive element (TRE). To study their role in gene regulation during early mammalian development, expression and transcription regulatory properties of their gene products were investigated during retinoic acid (RA) induced differentiation of P19 embryonal carcinoma (EC) cells. Our results show, that c-jun is expressed at low but detectable levels in undifferentiated P19 EC cells and at elevated levels in its RA differentiated derivatives, corresponding with increased expression of Jun and TRE binding activity. Jun D is constitutively expressed at constant levels in both undifferentiated and differentiated P19 cells, while jun B and c-fos are not expressed. Addition of TPA to undifferentiated P19 cells does not result in induction of c-jun, jun B and c-fos, while these genes are transiently induced in RA-differentiated P19 cells. In addition, TPA treatment resulted in expression of Fos and Jun protein in RA-differentiated, but not in undifferentiated P19 cells. Addition of TPA to P19 EC cells expressing low levels of TRE binding proteins is neither followed by transcriptional activation of the TRE report...Continue Reading

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Citations

Apr 1, 1994·Cell and Tissue Research·S E GuldenaarJ T McCabe
Mar 1, 1994·Mutation Research·J R Schlehofer
Apr 21, 1999·Brain Research. Brain Research Reviews·M WaltonM Dragunow
Nov 10, 2000·Brain Research. Molecular Brain Research·M DragunowM During
Feb 25, 1991·Nucleic Acids Research·R P de GrootW Kruijer
Apr 11, 1991·Nucleic Acids Research·R P de GrootW Kruijer
Sep 24, 2004·Biochemical and Biophysical Research Communications·Yi-Fen LeeChawnshang Chang
Jun 29, 2004·Biochemical and Biophysical Research Communications·Koichi OkumuraNoboru Nakajima
May 15, 1992·Biochemical and Biophysical Research Communications·T MomoiY Etoh
Jan 27, 1995·The Journal of Biological Chemistry·J RouleauM Szyf
Aug 29, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hong Seok ChoiZigang Dong
Feb 16, 2019·Nature Reviews. Urology·Sina JostesHubert Schorle
Jan 1, 1991·DNA Sequence : the Journal of DNA Sequencing and Mapping·S ShenW Kruijer
Sep 1, 1991·Molecular and Cellular Biology·K Macleod, M Plumb
Dec 1, 1993·Molecular and Cellular Biology·F Kihara-NegishiH Ariga
Dec 10, 1991·Biochimica Et Biophysica Acta·P Angel, M Karin
Nov 1, 1992·Critical Reviews in Oncology/hematology·M A Lea

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