Differential expression of Kv1.3 and Kv1.5 voltage-dependent K+ channels in human skeletal muscle sarcomas

Cancer Investigation
Joanna BielanskaAntonio Felipe

Abstract

Because Kv1.3 and Kv1.5 K(+) channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy.

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Citations

Feb 28, 2013·Pflügers Archiv : European journal of physiology·Daniela PalmeStephan M Huber
Aug 6, 2013·Cellular and Molecular Life Sciences : CMLS·Charles A GaleaRaymond S Norton
Dec 5, 2015·Expert Opinion on Therapeutic Targets·Mireia Pérez-VerdaguerAntonio Felipe
Nov 17, 2015·International Journal of Molecular Sciences·Jin WuBin Lin
Dec 18, 2014·Biochimica Et Biophysica Acta·Nuria ComesAntonio Felipe
Mar 3, 2019·Cancers·Clara Serrano-NovilloAntonio Felipe
May 28, 2019·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Isadora S OliveiraManuela B Pucca
Aug 14, 2020·Electromagnetic Biology and Medicine·C CecchettoS Vassanelli
Aug 5, 2019·Pflügers Archiv : European journal of physiology·Thiha AungSilke Haerteis
May 1, 2021·Pharmacology & Therapeutics·Vanessa ChecchettoIldiko Szabo
May 2, 2021·Medicinal Research Reviews·Špela GubičLucija P Mašič

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