Differential expression of metastasis-associated genes in papilla of vater and pancreatic cancer correlates with disease stage

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
H FriessM W Büchler

Abstract

Papilla of Vater cancer has a much better prognosis than pancreatic cancer. It is not known whether this is the result of differences in the tumor biology of the two malignancies. Because metastasis formation is a critical step in tumor progression and a negative prognostic factor, we compared the expression of nm23-H1 and KAI1, two metastasis-suppressing genes, in papilla of Vater cancer and pancreatic cancer. Analysis was performed in nine normal human papilla of Vater samples, 27 papilla of Vater cancers, 16 normal pancreatic samples, and 29 pancreatic cancers. Expression of nm23-H1 and KAI1 was analyzed by Northern blot analysis and in situ hybridization. In addition, immunohistochemistry was performed to localize the respective proteins. There was no difference in nm23-H1 and KAI1 mRNA expression levels in normal versus cancerous papilla of Vater samples. In contrast, nm23-H1 and KAI1 RNA expression was upregulated in early tumor stages of pancreatic cancer and reduced in advanced tumor stages. When expression of nm23-H1 and KAI1 RNA was analyzed by use of in situ hybridization, normal epithelial cells of the papilla of Vater exhibited mRNA staining intensity similar to that of papilla of Vater cancer cells. Similar levels...Continue Reading

References

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Citations

Feb 21, 2008·World Journal of Gastroenterology : WJG·Jian-Hua XuMin-Pei Liu
Oct 13, 2010·The Journal of Pathology·Hanna M Romanska, Fedor Berditchevski
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hyun-Ah LeeHansoo Lee
Sep 3, 2008·BMC Cancer·Peter Schirmacher, Markus W Büchler
Aug 29, 2013·Journal of Ophthalmology·Shawn C MaloneyMiguel N Burnier
Jun 12, 2003·World Journal of Gastroenterology : WJG·Li LiuYan-Qing Ding
Jul 20, 2004·World Journal of Gastroenterology : WJG·De-Hua WuYan-Qing Ding
Jan 7, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Jing-shi SuJuichi Kawamura
Feb 21, 2006·World Journal of Gastroenterology : WJG·Klaus L PrenzelPaul M Schneider
Oct 10, 2006·Future Oncology·Benjamin D HedleyAnn F Chambers
Nov 2, 2005·Cancer Letters·Wei M Liu, Xin A Zhang
May 15, 2003·Clinical Breast Cancer·Patricia S SteegMassimiliano Salerno

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