Abstract
Glioblastoma multiforme (GBM) is the most malignant primary brain tumor and more resistant to radiotherapy. However, hetero-radiosensitivity occurs in different patients. MicroRNAs (miRNAs) play important roles in the initiation and progression of a multitude of tumors. The study aims to examine the different microRNAs expression profiles of postoperative radiotherapy sensitive and resistant patients with GBM, to make an inquiry about their potential role and discover a certain set of radio-sensitivity markers. Three paired samples from six GBM patients who had only been treated with postoperative radiotherapy were selected, and then, they were divided into radiotherapy sensitive group and resistant group according to their overall survivals, local recurrence rates, and Karnofsky Performance Scale scores. Expression profiles of miRNAs in these two groups were determined by the method of microarray assay. Comparing with resistant patients, 13 miRNAs were significantly upregulated and 10 miRNAs were greatly downregulated in sensitive group. Among them, four miRNAs were validated by quantitative RT-PCR. The differentially expressed miRNAs and their putative target genes were revealed by bioformatic analysis to play a role in cell ...Continue Reading
References
Jan 11, 2001·Neurosurgery·T JokiP M Black
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jul 26, 2005·Biochemical and Biophysical Research Communications·S A CiafrèM G Farace
Dec 25, 2008·Methods in Molecular Biology·Hiroko Ohgaki
Jun 16, 2009·Biochemical and Biophysical Research Communications·Jana NovakovaJaroslav Michalek
Apr 13, 2010·DNA and Cell Biology·M Ahmad ChaudhryRomaica A Omaruddin
Aug 24, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xiao-Chun WangAi-Min Meng
Dec 15, 2010·Nature Reviews. Clinical Oncology·Naoko TakebeS Percy Ivy
Jan 5, 2011·Protein & Cell·Zhi HuangShideng Bao
Apr 2, 2011·Radiation Oncology·Olivier M NiemoellerClaus Belka
Jul 6, 2011·Molecular Neurobiology·Pilar González-GómezHelena Mira
Dec 15, 2011·Carcinogenesis·Mark T W TeoAnne E Kiltie
Sep 20, 2012·Cancer·Wei ZhangTao Jiang
Nov 28, 2013·Nucleic Acids Research·Ana Kozomara, Sam Griffiths-Jones
Feb 13, 2014·Journal of Cellular Biochemistry·Shuang LiuQiao Li
May 30, 2014·PloS One·Jie XiongXiaoning Peng
Jun 1, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francesco CelliniVincenzo Valentini
Citations
Jul 21, 2016·Oncotarget·Wanghao ChenQiaoyu Li
May 11, 2020·Aging·Lan JiangKun Lv
Aug 25, 2020·Oncology Nursing Forum·Mengyuan LiShuqing Xiao