Differential expression of miRNA patterns in renal cell carcinoma and nontumorous tissues.

Journal of Cancer Research and Clinical Oncology
Zhengjun YiChuanxiang Ma

Abstract

MiRNAs are short single stranded RNAs that are associated with gene regulation at the transcriptional and translational level. Changes in their expression were found in a variety of human cancers. In the present study, we aimed to investigate expression profiles of miRNA (miRNA) in the clear cell subtype of kidney cancer and to develop further understanding of the molecular mechanisms involved in the pathogenesis of renal cell carcinoma. We analyzed the miRNA expression profiles in 30 pairs of renal cell carcinoma and adjacent nontumorous tissue (NT), using a mammalian miRNA microarray containing whole human mature and precursor miRNA sequences. Real-time quantitative PCR was performed to confirm the array results. The miRNA microarray chip analysis identified 86 miRNAs differentially expressed in renal cell carcinoma tissues and a total of 38 miRNAs exhibited higher expression in the renal cell carcinoma samples than that in the NT samples, while 48 miRNA demonstrated lower expression in the renal cell carcinoma samples than that in the NT samples. Quantitative real-time PCR analysis confirmed microarray data. The report supports that many miRNA expressions were altered in renal carcinoma, whose expression profiling may provid...Continue Reading

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Citations

Jan 14, 2011·American Journal of Physiology. Renal Physiology·Kirti BhattZheng Dong
Mar 24, 2012·Journal of Translational Medicine·Martina RedovaOndrej Slaby
Jun 12, 2012·PloS One·Nirmalya DeyGoutam Ghosh Choudhury
Jan 15, 2014·Clinics and Research in Hepatology and Gastroenterology·Lidao BaoXianhua Ren
Aug 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yongqing GaoGaobo Yan
May 29, 2010·Journal of Cancer Research and Clinical Oncology·Wen GaoYongqian Shu
Oct 2, 2015·International Journal of Molecular Sciences·Michal FedorkoOndrej Slaby
Mar 31, 2015·Molecular Medicine Reports·Duqun ChenYongqing Lai
Jun 26, 2013·IUBMB Life·Qingqing WeiZheng Dong
Jan 13, 2012·Kidney International·Karthikeyan ChandrasekaranKandiah Jeyaseelan
Jan 15, 2011·Biochemical and Biophysical Research Communications·Martina RedovaOndrej Slaby
Oct 12, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Shunsuke ShinmeiWataru Yasui
Jun 10, 2010·Clinical Science·Chiara TaurinoAnna F Dominiczak
Jan 31, 2015·Journal of Cancer Research and Clinical Oncology·Yu-Zheng GeRui-Peng Jia
Dec 1, 2014·Molecular Genetics and Genomics : MGG·Zhigui LiZhuo Yang
Jul 9, 2010·Journal of Experimental & Clinical Cancer Research : CR·Ondrej SlabyRostislav Vyzula
Feb 14, 2012·The American Journal of Pathology·Zsuzsanna LichnerGeorge M Yousef
Nov 4, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jie ZhuXu Zhang
Apr 22, 2017·Experimental Biology and Medicine·Xiang SunLijuan Wan
May 30, 2019·Journal of Cellular Physiology·Monireh KhordadmehrBehzad Baradaran

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