Differential expression of mitogen-activated protein kinases and immediate early genes fos and jun in thalamus in schizophrenia

Progress in Neuro-psychopharmacology & Biological Psychiatry
S V Kyosseva

Abstract

Despite a growing body of evidence demonstrating that mitogen-activated protein (MAP) kinase pathways play an important physiological role in the CNS, little is known about their role and function in various mental disorders including schizophrenia. Our previous studies have shown increased expression of several intermediates of the extracellular signal-regulated (ERK) cascade and downstream transcription targets in cerebellar vermis without any changes in mesopontine tegmentum and Brodmann's area 10 in patients with schizophrenia. Given the evidence for abnormalities in schizophrenia in a neural circuit involving the cerebellum and thalamus, the present study was conducted to examine the expression of MAP kinases extracellular signal-regulated kinase (ERK), c-Jun-N-terminal kinase (JNK) and p38, as well as immediate early genes fos (c-fos and fos B) and jun (c-jun, jun B and jun D) using a Western blot analysis and reverse transcription polymerase chain reaction (RT-PCR) in postmortem thalamus from schizophrenic and control subjects. There were significant increase in ERK2, c-fos and c-jun protein and mRNA levels in thalamus of patients with schizophrenia relative to controls. No statistically significant differences were foun...Continue Reading

References

Feb 14, 1992·Biochemical and Biophysical Research Communications·H OwakiT D Geppert
Apr 1, 1990·Journal of Neurochemistry·J C Miller
Sep 1, 1988·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A Carlsson
Mar 1, 1995·Journal of Neurobiology·T Curran, J I Morgan
Jan 1, 1996·The American Journal of Psychiatry·B M Cohen, W Wan
Dec 1, 1995·Molecular Reproduction and Development·R J Davis
Oct 4, 1996·The Journal of Biological Chemistry·J D English, J D Sweatt
Oct 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·A J Whitmarsh, R J Davis
Oct 1, 1996·Progress in Neurobiology·D G Herrera, H A Robertson
Feb 1, 1997·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·N C Andreasen
Apr 1, 1997·Current Opinion in Cell Biology·M KarinE Zandi
Aug 1, 1997·The Journal of Biological Chemistry·J D English, J D Sweatt
Feb 7, 1998·Journal of Neurochemistry·R V BhatK M Walton
Mar 7, 1998·Psychopharmacology·B M CohenH Konieczna
Apr 29, 1998·Molecular Neurobiology·K Fukunaga, E Miyamoto
Oct 2, 1998·Biological Psychiatry·R S Duman
Jun 5, 1999·Cellular and Molecular Life Sciences : CMLS·W Tischmeyer, R Grimm
Sep 3, 1999·Biological Psychiatry·S V KyossevaC N Karson
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·A AlessandriniJ V Bonventre
Dec 14, 1999·Learning & Memory·J C SelcherJ D Sweatt
Mar 17, 2000·Brain Research. Brain Research Reviews·F M Benes
Mar 30, 2000·The American Journal of Psychiatry·R F DeickenN Schuff
Jun 6, 2000·Biological Psychiatry·K A YoungD C German
Jun 14, 2000·Current Opinion in Neurobiology·D R Kaplan, F D Miller
Nov 4, 2000·The American Journal of Psychiatry·H M IbrahimJ H Meador-Woodruff
Feb 13, 2001·Learning & Memory·J C SelcherJ D Sweatt
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Sep 5, 2001·The American Journal of Psychiatry·D C Goff, J T Coyle

❮ Previous
Next ❯

Citations

Apr 18, 2008·The Cerebellum·S Hossein FatemiRobert W Sidwell
Nov 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adam J FunkJames H Meador-Woodruff
Mar 6, 2013·Nucleic Acids Research·Shengjun HongMomiao Xiong
Aug 10, 2006·Clinical and Experimental Pharmacology & Physiology·Valin RejaPaul M Pilowsky
Nov 27, 2008·BMC Bioinformatics·Alexander L RichardsLesley Jones
Feb 9, 2016·Neuroscience·S KálmánK Mirnics
Aug 11, 2011·Seminars in Cell & Developmental Biology·Barbara PortonHung-Teh Kao
Mar 2, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nikkie F M Olde LoohuisArmaz Aschrafi
Oct 20, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mikhail KalinichevDeclan N C Jones
Nov 27, 2015·Schizophrenia Bulletin·Yong XuFuquan Zhang
Jul 5, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·E Esmaeilzadeh-GharehdaghiM Ohadi
Jan 3, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Concetta CrisafulliAlessandro Serretti
Feb 22, 2017·Molecular Psychiatry·A Busquets-GarciaG Marsicano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

© 2021 Meta ULC. All rights reserved