PMID: 9166718Jun 1, 1997Paper

Differential expression of multiple somatostatin receptors in the rat cerebellum during development

Journal of Neurochemistry
Cécile ViolletP Leroux

Abstract

The present study describes the expression pattern of somatostatin receptor genes during the development of rat cerebellum. Characterization of somatostatin receptors was carried out by binding studies using receptor subtype-selective ligands in the germinative epithelium and granule cell layer of the cerebellum from postnatal day 4 (P4) to P21 and in granule cell cultures. Quantitative reverse transcription-PCR carried out for the five receptor subtype mRNAs in cerebellar extracts showed that sst1 mRNAs are predominant at the end of gestation. A transient high expression of the sst2 gene was observed from P7 to P14. In parallel, high levels of binding sites sensitive to sst2 ligands were detected in the granule cell germinative epithelium and in granule cell cultures. sst3 mRNAs rapidly increased from P14 and became the predominant form at P21, but respective binding sites were not detected. Whereas sst4 mRNA levels were generally low, those of sst5 were nearly undetectable. Reverse transcription-PCR carried out in granule cell cultures revealed the relative abundance of sst mRNAs as follows: sst2 > sst1 > sst3 = sst4. sst5 mRNA was undetectable. The results show the expression of four somatostatin receptor genes, but only thr...Continue Reading

Citations

May 11, 2000·The Journal of Comparative Neurology·E Bologna, P Leroux
Sep 19, 2012·Developmental Neuroscience·Daniel BodmerVesna Radojevic
Mar 11, 2000·British Journal of Pharmacology·C PetrucciP Bagnoli
Jan 10, 2002·Nature·Elina Yacubova, Hitoshi Komuro
Dec 14, 2007·Developmental Neuroscience·Yulan JiangHitoshi Komuro
Aug 5, 2006·Endocrinology·Brian C Trainor, Hans A Hofmann
Oct 16, 1999·Brain Research. Molecular Brain Research·G Hervieu, P C Emson
Apr 21, 1999·Brain Research. Brain Research Reviews·A K Mehta, M K Ticku
Aug 30, 2008·Molecular and Cellular Neurosciences·Olaf HardtAndreas Bosio

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