Differential expression of neural-cadherin in pulmonary epithelial tumours

D L ZyngerA V Yeldandi


Neural (N)-cadherin belongs to a group of transmembrane molecules with a crucial role in tissue morphogenesis and maintenance of an epithelioid phenotype and increased N-cadherin expression is implicated in tumour progression and dedifferentiation. The aim was to determine whether evaluation of N-cadherin in pulmonary tumours might assist in identifying lesions with more aggressive potential. One hundred and fifty-five pulmonary lesions were analysed for N-cadherin expression using immunohistochemistry, including neuroendocrine hyperplasia (n = 3), typical carcinoid (n = 59), atypical carcinoid (n = 12), small cell lung carcinoma (n = 11), large cell neuroendocrine carcinoma (n = 12), adenocarcinoma (n = 35) and squamous cell carcinoma (n = 23). Lymph node status was correlated with immunohistochemical expression. N-cadherin expression was demonstrated in all cases of neuroendocrine hyperplasia, 96% of typical carcinoids, 83% of atypical carcinoids, 63% of the small cell lung carcinomas and 32% of large cell neuroendocrine carcinomas. Over 90% of the adenocarcinomas and 100% of the squamous cell carcinomas were negative. Increased N-cadherin expression in typical carcinoids was associated with negative lymph node status (P < 0....Continue Reading


Jul 11, 1992·The Annals of Thoracic Surgery·D H HarpoleW G Wolfe
Jan 1, 1996·Acta Anatomica·C BirchmeierB Brand-Saberi
Aug 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S M Frisch
Oct 20, 1998·The American Journal of Surgical Pathology·S LantuejoulE Brambilla
Aug 3, 2000·Archives of Pathology & Laboratory Medicine·A C HanH Salazar
Sep 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Y LiuJ F Silverman
Jul 20, 2002·Journal of Neuro-oncology·Satoshi UtsukiKiyotaka Fujii
Jan 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yasumasa MatsukiYasuyuki Sasaguri
Mar 14, 2003·Seminars in Oncology·Alan B Sandler
Mar 27, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T A ZarkaN G Rosenblum
Dec 6, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shi-Xu JiangIsao Okayasu
Jan 23, 2004·The New England Journal of Medicine·Alexander Spira, David S Ettinger
May 22, 2004·Annals of the New York Academy of Sciences·Rachel B HazanKimita Suyama
Sep 7, 2004·The International Journal of Developmental Biology·Lara D M Derycke, Marc E Bracke

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