Differential expression of neuropsin and protease M/neurosin in oligodendrocytes after injury to the spinal cord

Glia
R TerayamaShigetaka Yoshida

Abstract

Neuropsin and protease M/neurosin are serine proteases expressed by neurons and glial cells, and serve a variety of functions in the central nervous system (CNS). The current study demonstrates changes in the expression of these proteases following hemisection of the mouse spinal cord. Within unlesioned spinal cord, neuropsin mRNA expression was occasionally observed in the gray but not white matter, while the level of protease M/neurosin mRNA was higher in the white matter. After injury to the spinal cord, neuropsin mRNA expression was induced in the white matter in the area immediately adjacent to the lesion, peaking at 4 days post-injury and disappearing by 14 days. Enhanced expression of protease M/neurosin mRNA was observed throughout the white and gray matter surrounding the lesion, peaking at 4 days and persisting for 14 days. Neuropsin mRNA was expressed predominantly by CNPase-positive oligodendrocytes. Furthermore, most of these cells were also associated with immunoreactivity for protease M/neurosin protein. Within unlesioned spinal cord, most protease M/neurosin mRNA-expressing cells were CNPase-positive oligodendrocytes, and a substantial fraction of these cells also showed immunoreactivity for NG2, a marker for ol...Continue Reading

References

Jan 1, 1990·Advances in Experimental Medicine and Biology·N W SeedsJ Schoonmaker
Jan 1, 1989·Annual Review of Neuroscience·J R Sanes
Oct 27, 1980·Brain Research·S SzuchetB G Arnason
Jan 1, 1983·Annual Review of Physiology·J R Sanes
Sep 25, 1981·Science·A Krystosek, N W Seeds
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y LiuP G Nelson
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·L J HouenouB W Festoff
Jul 1, 1994·Neuroscience Research·S YoshidaS Shiosaka
Mar 1, 1994·Journal of Neurobiology·Y LiuP G Nelson
Oct 1, 1995·Journal of Neurotrauma·I Mocchetti, J R Wrathall
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·S E TsirkaS Strickland
Apr 29, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Z L ChenS Yoshida
Jun 6, 1998·The Journal of Biological Chemistry·C ShimizuS Shiosaka
Jun 26, 1998·Experimental Neurology·H S KeirsteadW F Blakemore
Sep 2, 1998·Cell and Tissue Research·C C Stichel, H W Müller
Apr 10, 1999·Brain Research·K TomizawaS Yoshida
Oct 16, 1999·Brain Research. Molecular Brain Research·H YamanakaS Yoshida
Mar 29, 2001·Neuroscience Research·X P HeS Yoshida
Feb 9, 2002·Science·Martin E Schwab
May 23, 2002·Brain : a Journal of Neurology·I A ScarisbrickM Rodriguez
Feb 19, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·George M YousefEleftherios P Diamandis
Jun 10, 2003·The Journal of Comparative Neurology·Julie M SrogaPhillip G Popovich

❮ Previous
Next ❯

Citations

Apr 10, 2007·Biochemistry·Sachiko I BlaberMichael Blaber
Jun 20, 2012·Journal of Neurotrauma·Krishna Kumar VeeravalliJasti S Rao
Oct 11, 2012·PloS One·Eduardo Martínez-MorilloEleftherios P Diamandis
Jun 28, 2006·Biological Chemistry·Constantina D PetrakiEleftherios P Diamandis
Apr 17, 2012·Biological Chemistry·Isobel A ScarisbrickAlexander G Vandell
Aug 14, 2008·Protein Science : a Publication of the Protein Society·Hyesook YoonMichael Blaber
Dec 7, 2007·British Journal of Pharmacology·R Ramachandran, M D Hollenberg
Sep 22, 2006·The European Journal of Neuroscience·I A ScarisbrickM Rodriguez
May 8, 2013·Journal of Neurochemistry·Hyesook YoonIsobel A Scarisbrick
Nov 4, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Jane Bayani, Eleftherios P Diamandis
May 9, 2014·Journal of the Neurological Sciences·Ana Rodríguez-RodríguezFrancisco Murillo-Cabezas
Feb 24, 2015·Nature Reviews. Drug Discovery·Ioannis PrassasEleftherios P Diamandis
May 18, 2020·The Journal of Physiological Sciences : JPS·Lina BukowskiPer Qvist
Oct 12, 2017·Scientific Reports·Sheri L PetersonAileen J Anderson
Feb 13, 2020·F1000Research·Michelle ChenEleftherios P Diamandis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.