PMID: 9658143Jul 11, 1998Paper

Differential expression of Nur77 family members in human T-lymphotropic virus type 1-infected cells: transactivation of the TR3/nur77 gene by Tax protein

Journal of Virology
X ChenX Liu

Abstract

We analyzed the differential expression and regulation of three members of the Nur77 transcription factor family by the human T-lymphotropic virus type 1 (HTLV-1) Tax protein. We have demonstrated that in both HTLV-1-infected cells and Tax-expressing JPX-9 cells, TR3/nur77 is highly expressed, whereas neither NOR-1 nor NOT expression is detectable. Transient transfection analysis further confirmed the Tax transactivation of the TR3/nur77 promoter but not the NOR-1 promoter in different cell types. Furthermore, expression of a luciferase reporter gene driven by the NGFI-B (rat homolog of TR3/Nur77) response element (NBRE) provided evidence that Tax-mediated transactivation resulted in the induction of a functional protein. Cotransfection assays with the TR3/nur77 promoter sequence or the NBRE binding motif together with a series of Tax mutants have shown that Tax-induced TR3/nur77 expression is mediated by CREB/ATF-related transcription factors.

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Citations

Jun 5, 2003·The Journal of Experimental Medicine·Sung Ouk KimJiahuai Han
Sep 7, 2002·Antioxidants & Redox Signaling·Katerina ChlichliaKhashayarsha Khazaie
Nov 9, 2001·Biochemical and Biophysical Research Communications·M O LeeS J Kim
Oct 1, 2011·Future Microbiology·Matthew S Miller, Joe S Mymryk

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