Differential expression of Öbek controls ploidy in the Drosophila blood-brain barrier

Development
Selen ZülbaharChristian Klämbt

Abstract

During development, tissue growth is mediated by either cell proliferation or cell growth, coupled with polyploidy. Both strategies are employed by the cell types that make up the Drosophila blood-brain barrier. During larval growth, the perineurial glia proliferate, whereas the subperineurial glia expand enormously and become polyploid. Here, we show that the level of ploidy in the subperineurial glia is controlled by the N-terminal asparagine amidohydrolase homolog Öbek, and high Öbek levels are required to limit replication. In contrast, perineurial glia express moderate levels of Öbek, and increased Öbek expression blocks their proliferation. Interestingly, other dividing cells are not affected by alteration of Öbek expression. In glia, Öbek counteracts fibroblast growth factor and Hippo signaling to differentially affect cell growth and number. We propose a mechanism by which growth signals are integrated differentially in a glia-specific manner through different levels of Öbek protein to adjust cell proliferation versus endoreplication in the blood-brain barrier.

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Citations

Feb 26, 2020·Developmental Neurobiology·Jonas BitternChristian Klämbt
Sep 5, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Simon Gemble, Renata Basto
Nov 18, 2018·Glia·Kerem YildirimChristian Klämbt
Jun 18, 2020·Frontiers in Cell and Developmental Biology·Dani RenWei Guo
Oct 30, 2020·Scientific Reports·Chia-Kang TsaoY Henry Sun

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