Differential expression of Oct-4, CD44, and E-cadherin in eutopic and ectopic endometrium in ovarian endometriomas and their correlations with clinicopathological variables.

Reproductive Biology and Endocrinology : RB&E
Ceyda Sancakli UstaErtan Adali

Abstract

Endometriosis is an estrogen-dependent inflammatory disease that often causes infertility and chronic pelvic pain. Although endometriosis is known as a benign disease, it has demonstrated characteristics of malignant neoplasms, including neoangiogenesis, tissue invasion, and cell implantation to distant organs. Octamer-binding protein 4 (Oct-4) is a molecular marker for stem cells that plays an essential role in maintaining pluripotency and self-renewal processes in various types of benign and malignant tissues. CD44 is a multifunctional cell surface adhesion molecule that acts as an integral cell membrane protein and plays a role in cell-cell and cell-matrix interactions. E-cadherin is an epithelial cell-cell adhesion molecule that plays important role in the modulation of cell polarization, cell migration, and cancer metastasis. The aim of this study was to investigate the expression patterns of Oct-4, CD44, and E-cadherin in eutopic and ectopic endometrial tissues from women with endometrioma compared to control endometrial tissues from women without endometrioma. In the present study, Oct-4, CD44, and E-cadherin expressions were evaluated in eutopic and ectopic endometrial tissue samples from women with endometrioma (n = 32...Continue Reading

References

Mar 29, 1990·Nature·H R SchölerP Gruss
Aug 1, 1995·Human Pathology·N YaegashiM Nakamura
May 1, 1994·Nature Genetics·J I RisingerJ Boyd
Jan 1, 1997·Advances in Cancer Research·D NaorD Ish-Shalom
Apr 11, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W B NothnickO W Tawfik
Jan 31, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R Gazvani, A Templeton
Apr 23, 2002·Acta Obstetricia Et Gynecologica Scandinavica·Christophe PonceletEmile Daraï
May 23, 2002·Genes & Development·Michele BoianiK John McLaughlin
Jan 20, 2006·Molecular Human Reproduction·C MatthaiA Kolbus
Jun 8, 2007·Nature·Keisuke OkitaShinya Yamanaka
Mar 7, 2008·Journal of Cell Science·Margaret J WheelockKeith R Johnson
Apr 30, 2008·Annals of the New York Academy of Sciences·Isaac E Sasson, Hugh S Taylor
Dec 6, 2008·The Prostate·Paula SotomayorWendy J Huss
Apr 24, 2010·Reproductive Biology and Endocrinology : RB&E·Eva-Katrin BentzClemens B Tempfer
Jul 8, 2010·Fertility and Sterility·Christophe PonceletMarianne Ziol
Nov 16, 2010·Fertility and Sterility·Arianna PacchiarottiMassimo Moscarini
Mar 16, 2011·Annals of the New York Academy of Sciences·Paula Gabriela Marin FigueiraHugh Taylor
Aug 27, 2011·Breast Cancer Research : BCR·Kateryna Shostak, Alain Chariot
Jan 8, 2013·Fertility and Sterility·Jui-Hung ChangChii-Ruey Tzeng
Aug 22, 2013·Journal of Minimally Invasive Gynecology·João Siufi NetoMaurício Simões Abrão
May 3, 2014·Journal of the Turkish German Gynecological Association·Hüseyin SahinAli Rüştü Ergür
Mar 11, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Essam R OthmanAyman Al-Hendy
Oct 31, 2017·The Tohoku Journal of Experimental Medicine·Akin UstaErtan Adali
Dec 13, 2017·The Journal of Steroid Biochemistry and Molecular Biology·Azar PazhohanAligholi Sobhani
Apr 7, 2018·Reproductive Sciences·Jennifer F KnudtsonRobert S Schenken
Oct 24, 2018·International Journal of Molecular Sciences·Nicola TempestDharani K Hapangama

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