PMID: 9176081Apr 1, 1997Paper

Differential expression of oestrogen receptor and oestrogen inducible genes in gastric mucosa and cancer

Gut
S SinghM J Langman

Abstract

Evidence exists for a role for oestrogen in gastric cancer. The incidence of gastric cancer is much higher in men than in woman, and a similar sex difference is also seen in a rat experimental model of gastric cancer. Evidence for a functional oestrogen receptor in normal gastric mucosa and cancer has been sought. Oestrogen receptor and the oestrogen inducible genes pS2 and ERD5 were sought by northern blot analysis and in situ hybridisation and immunohistochemistry. Oestrogen receptor protein was studied by enzyme immunoassay. mRNA for oestrogen receptor was detected in cancer and normal gastric mucosa. Enzyme immunoassay for oestrogen receptor showed a mean of 1.8 fmol/mg protein in cancer and 13.7 fmol/mg in paired normal mucosa. The oestrogen inducible genes pS2 and ERD5 were also detected in both cancer and normal mucosa, with expression localised to epithelium. Expression of pS2 was lower in cancer compared with normal mucosa, whereas ERD5 expression was higher in cancer. Significant amounts of oestrogen receptor were expressed in gastric mucosa with a lower amount in cancer. Oestrogen inducible genes were also expressed differentially but were not found to correlate closely with oestrogen receptor. Oestrogen receptor fun...Continue Reading

Citations

Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Manami InoueSuketami Tominaga
May 20, 1998·Pathology, Research and Practice·C HäckelA Roessner
Oct 24, 2007·The Journal of Surgical Research·Outi Nylander-KoskiHarri Mustonen
Jun 16, 2009·Molecular and Cellular Endocrinology·A M HoganD C Winter
Sep 13, 2013·Biochemical and Biophysical Research Communications·Narayanan Sathiya PandiSuriliyandi Rajendran
May 26, 1998·Japanese Journal of Cancer Research : Gann·M S WuJ T Lin
Jun 26, 1999·The British Journal of Surgery·R J LongmanR Poulsom
Oct 7, 2008·World Journal of Gastroenterology : WJG·Milena Saqui-SalcesIgnacio Camacho-Arroyo
Apr 3, 2008·British Journal of Cancer·S BahmanyarW Ye
Mar 5, 2016·World Journal of Gastroenterology : WJG·Muhammad Saif Ur Rahman, Jiang Cao
May 24, 2006·World Journal of Gastroenterology : WJG·Shu-Qing ShiJian-Ming Yang
Jul 26, 2008·World Journal of Surgical Oncology·Antonio CiullaGaspare Genova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of the Royal College of Surgeons of England
F Missotten
Annals of the Royal College of Surgeons of England
J A Smallwood, R Morgan
International Journal of Colorectal Disease
A M Hogan, D C Winter
© 2021 Meta ULC. All rights reserved