Differential expression of opioid receptor genes in human lymphoid cell lines and peripheral blood lymphocytes

Journal of Neuroimmunology
M J WickH H Loh

Abstract

The existence of receptors for opioid compounds on cells of the immune system has long been hypothesized, but has been very difficult to demonstrate unequivocally. We have used reverse-transcription polymerase chain reaction to obtain cDNA clones from the human MOLT-4 and CEM-3 T-leukemic cell lines which are nearly identical to portions of the delta and kappa opioid receptor cDNAs recently isolated from human brain and placenta, respectively. Northern analyses with riboprobes derived from the delta and kappa opioid receptor clones indicate these sequences are expressed at low levels in human peripheral blood lymphocytes and in several human lymphoid cell lines. Sequences corresponding to the mu opioid receptor cDNA were not detected in this study. The results suggest that delta and kappa opioid receptors may be responsible for mediating some direct effects of opioids in immune cells.

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B L KiefferC G Hirth
Dec 28, 1992·Science·C J EvansR H Edwards
Nov 2, 1992·European Journal of Pharmacology·J M BidlackD M Lawrence
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D D TaubT J Rogers
Jan 1, 1988·Annual Review of Immunology·N E Sibinga, A Goldstein
Feb 1, 1985·Neuropeptides·M R RuffC B Pert
Jun 13, 1986·Biochemical and Biophysical Research Communications·S M Kazmi, R K Mishra
Jan 1, 1974·Annual Review of Medicine·D B Louria
Dec 1, 1993·Trends in Neurosciences·T Reisine, G I Bell
Mar 1, 1994·Trends in Neurosciences·G R UhlG Pasternak
Apr 17, 1995·Biochemical and Biophysical Research Communications·M SedqiH H Loh
Apr 26, 1995·Biochemical and Biophysical Research Communications·L F ChuangL Yu

❮ Previous
Next ❯

Citations

Dec 19, 2000·Biochemical and Biophysical Research Communications·S SuzukiR Y Chuang
Dec 16, 2011·Amino Acids·Jana Ninković, Sabita Roy
Apr 23, 2004·Life Sciences·Antonella D'AmbrosioFrancesca Quintieri
Mar 10, 2001·European Journal of Pharmacology·A Kulkarni-NarlaD R Brown
Dec 18, 2001·Pharmacology & Therapeutics·P Mayer, V Höllt
Jan 1, 2003·Journal of Neuroimmunology·Claire Gavériaux-RuffBrigitte L Kieffer
Jun 4, 1998·Journal of Neuroimmunology·B M SharpJ M Bidlack
Jun 4, 1998·Journal of Neuroimmunology·J J MaddenD Ketelsen
Nov 17, 1998·Journal of Neuroimmunology·M S PampuschM P Murtaugh
Mar 14, 2001·Drug and Alcohol Dependence·J J MaddenR M Donahoe
Oct 19, 2010·Journal of Leukocyte Biology·Christine HappelThomas J Rogers
Mar 31, 2011·Journal of Leukocyte Biology·Matthew J FinleyThomas J Rogers
Jun 24, 2014·Biochemistry. Biokhimii︠a︡·S V Gein
Nov 1, 1996·Neurochemical Research·S Roy, H H Loh
Apr 18, 2009·British Journal of Pharmacology·Z ZídekE Kmonícková
Sep 20, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A AndersonL S Kean
Jan 15, 2009·Cancer Science·Hitoshi OhmoriHiroki Kuniyasu
Sep 23, 1998·Biochemical Pharmacology·B M SharpP K Peterson
Nov 3, 2005·Biochemical and Biophysical Research Communications·Souzan SalemiHaiko Sprott
May 3, 2003·Virology·Amber D SteeleThomas J Rogers
Oct 8, 1999·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·E EsenO Akhan
Sep 27, 2018·The Journal of Pharmacology and Experimental Therapeutics·Saadet InanMartin W Adler
Mar 5, 2004·The Journal of Biological Chemistry·Cheol Kyu HwangHorace H Loh
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Khanh Nguyen, Bonnie C Miller
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer KelschenbachSabita Roy
Mar 21, 2020·Frontiers in Immunology·Halina Machelska, Melih Ö Celik
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B M SharpP K Peterson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.