Differential expression of p120 catenin in glial cells of the adult rat brain

The Journal of Comparative Neurology
Norbert ChauvetMonica Prieto

Abstract

p120 catenin (p120ctn) is involved in the regulation of cadherin-mediated adhesion and the dynamic organization of the actin cytoskeleton by modulating RhoGTPase activity. We have previously described the distribution of p120ctn during rat brain development and provided substantial evidence for the potential involvement of p120ctn in morphogenetic events and plasticity in the central nervous system. Here, we analyzed the cellular and ultrastructural distribution of p120ctn in glial cells of the adult rat forebrain. The highest intensity of immunostaining for p120ctn was found in cells of the choroid plexus and ependyma and was mainly restricted to the plasma membrane. However, p120ctn was almost absent from astrocytes. In contrast, in tanycytes, a particular glial cell exhibiting remarkable morphological plasticity, p120ctn, was localized at the plasma membrane and also in the cytoplasm. We show that a large subpopulation of oligodendrocytes expressed multiple isoforms, whereas other neural cells predominantly expressed isoform 1, and that p120ctn immunoreactivity was distributed through the cytoplasm and at certain portions of the plasma membrane. Finally, p120ctn was expressed by a small population of cortical NG2-expressing ...Continue Reading

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Citations

Dec 22, 2009·Acta Neuropathologica·Marc R Del Bigio
Sep 28, 2013·Nature Genetics·David L SchonbergJeremy N Rich
Oct 10, 2006·Biochimica Et Biophysica Acta·Panos Z Anastasiadis
Jun 13, 2015·PloS One·Antonis KourtidisPanos Z Anastasiadis

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