Differential expression of progestin receptor isoforms in the hypothalamus, pituitary, and endometrium of rhesus macaques

Endocrinology
C L Bethea, A A Widmann

Abstract

The progestin receptor exists in at least two isoforms: a long form (PR-B) and a short form (PR-A), which can be separated and detected with Western blot analysis. It has been suggested from in vitro transfection experiments that differential expression of the two isoforms may provide one mechanism for tissue specific actions of progesterone (P). However, more information from in vivo experimentation is needed. It has been reported that P down-regulates the expression of PR in the endometrium and pituitary of E primed macaques. However, PR protein and PR messenger RNA expression in the hypothalamus is maintained with P treatment of E-primed macaques. Thus, there is tissue-specific regulation of PR by its cognate ligand in the nonhuman primate. To gain insight into the tissue-specific regulation of PR by P, we questioned whether differential expression of the isoforms of PR exists in the endometrium, pituitary, and hypothalamus of rhesus monkeys. The expression of PR-A and PR-B was examined after E (28-30 days) and E + P (14 days E + 14 days E + P) treatment in the primate endometrium, pituitary, and hypothalamus. After E or E + P treatment, the levels of PR-A were 5 times higher than PR-B in the endometrium. PR-A was 1.6-fold h...Continue Reading

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Citations

Feb 11, 2019·Hormone Molecular Biology and Clinical Investigation·Nicola PluchinoAndrea R Genazzani
Aug 31, 2000·Endocrinology·J L Turgeon, D W Waring
Jul 22, 2016·Hormone Molecular Biology and Clinical Investigation·Nicola PluchinoAndrea R Genazzani
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·X FangB F Mitchell
Nov 22, 2001·The Journal of Biological Chemistry·Jennifer K RicherKathryn B Horwitz
Mar 22, 2002·Frontiers in Neuroendocrinology·Cynthia L BetheaJohn M Streicher
Mar 22, 2001·Frontiers in Neuroendocrinology·J E LevineM Szabo

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