Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma.

World Journal of Gastroenterology : WJG
Wei-Wei DongWen-Hua Xiao

Abstract

To investigate the association of Rab27A and Rab27B expression with clinicopathological characteristics and prognosis of hepatocellular carcinoma (HCC). We used reverse transcription polymerase chain reaction (RT-PCR), real-time PCR, and Western blotting to detect Rab27A and Rab27B mRNA and protein expression in 5 human HCC lines and the immortalized hepatic HL-7702 cell line. We further examined 148 primary HCC samples matched with adjacent normal tissue and 80 non-HCC specimens by immunohistochemistry to evaluate the correlation of Rab27A and Rab27B expression with clinicopathological features and prognosis. Our data showed that Rab27A and Rab27B were differentially expressed in cell lines and primary HCC tumors. Rab27A mRNA and protein were detected in 67% (4/6) of human cell lines and 80% (4/5) of HCC cell lines, while Rab27B was found in 50% (3/6) of human lines and 40% (2/5) of HCC lines. Rab27A expression was higher in primary HCC (46.2%, 66/143) than in matched adjacent tissue (24.3%, 33/136, P < 0.001), whereas immunopositivity for Rab27B was lower in primary HCC (57.4%, 81/141) than in matched adjacent tissue (87.5%, 119/136, P < 0.001). Analysis of clinicopathological characteristics of 148 HCC specimens revealed sig...Continue Reading

References

Oct 1, 1978·The American Journal of Medicine·C GriscelliM Prunieras
Aug 17, 1999·Current Opinion in Cell Biology·P Chavrier, B Goud
Nov 26, 1999·Gene·T TolmachovaM C Seabra
Jun 3, 2000·Nature Genetics·G MénaschéG de Saint Basile
Nov 8, 2001·Journal of Molecular Biology·J B Pereira-Leal, M C Seabra
Apr 17, 2002·Endocrinology·Shengli ZhaoTetsuro Izumi
May 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·Karine Croizet-BergerMarie-France van den Hove
Jul 18, 2002·The Journal of Clinical Investigation·Duarte C BarralMiguel C Seabra
Dec 25, 2002·Cancer Cell·Andrew M Chan, Thomas Weber
Nov 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yanru ChenGert Kreibich
Apr 28, 2004·The American Journal of Pathology·Joost P J J HegmansBart N Lambrecht
Sep 29, 2004·Biochemical and Biophysical Research Communications·Xuequn ChenJohn A Williams
Oct 27, 2004·Nature Medicine·Kwai Wa ChengGordon B Mills
Apr 5, 2005·Cancer Research·Kwai W ChengGordon B Mills
Aug 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bianka L GrosshansPeter Novick
Jun 16, 2007·Gastroenterology·Hashem B El-Serag, K Lenhard Rudolph
Aug 1, 2007·Endocrine Journal·Tetsuro Izumi
Jun 10, 2008·Recent Patents on Anti-cancer Drug Discovery·Paul K Wright
May 21, 2010·Journal of the National Cancer Institute·An HendrixWendy Westbroek
Dec 15, 2010·Molecular Cancer·Dhatchayini Subramani, Suresh K Alahari
Mar 2, 2011·The American Journal of Pathology·Gregoire MignotFrançois Ghiringhelli

❮ Previous
Next ❯

Citations

Oct 5, 2015·Cytotechnology·Johann Mar GudbergssonMeg Duroux
Feb 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kejia WangLi Wei
Dec 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hong-jun WangChuan-lu Jiang
Nov 28, 2012·Biochemical Society Transactions·Chiara Recchi, Miguel C Seabra
Jan 13, 2015·Gastroenterology Research and Practice·Jun BaoLiming Tang
Jun 14, 2015·Diagnostic Pathology·Chuanbing ShiPingsheng Chen
Mar 1, 2013·MedChemComm·Joshua D Ochocki, Mark D Distefano
Nov 28, 2014·Medical Oncology·Qingqing WangJianfei Huang
Jan 24, 2016·Biochimica Et Biophysica Acta·Zhihao XingXiangyin Kong
Jul 13, 2016·The Journal of Cell Biology·Seema SinhaAlissa M Weaver
Jun 25, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yaqi DaiWentao Xu
May 15, 2013·International Journal of Molecular Sciences·An Hendrix, Olivier De Wever
Dec 18, 2018·International Journal of Cancer. Journal International Du Cancer·Dajiang GuoKimberley A Beaumont
Feb 5, 2019·International Journal of Cancer. Journal International Du Cancer·Hongyan ChenDaru Lu
Apr 6, 2019·Acta Crystallographica. Section D, Structural Biology·Mostafa JamshidihaRandy J Read
Aug 8, 2018·Cell Communication and Signaling : CCS·Zhihong LiTang Liu
Jun 9, 2019·Nature Communications·Tian-Wei ChenDong Xie
Jun 11, 2016·Oncotarget·Marc Ruiz-MartinezMariano Monzo
May 25, 2013·World Journal of Gastroenterology : WJG·Wei SunYou-Yong Lu
Mar 8, 2017·Cancer Cell International·Dabing HuangShilian Hu
Aug 18, 2020·Cancer Management and Research·Fengqiang YuChun Chen
Dec 8, 2020·Frontiers in Molecular Biosciences·Thomas S van SolingeMarike L D Broekman
Dec 8, 2020·The International Journal of Biochemistry & Cell Biology·Yu DaiYu Jiang

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