Differential expression of RON in small and non-small cell lung cancers

Genes, Chromosomes & Cancer
Rajani KantetiRavi Salgia

Abstract

RON is a MET related receptor tyrosine kinase (RTK) and its natural ligand is macrophage stimulating protein (MSP). RON plays a very important role in the regulation of inflammation. Several studies have previously reported overexpression of RON in a variety of cancers including lung and identified numerous RON alternate splice forms that very likely contribute to tumor growth and metastasis. Here, we have analyzed the expression of total RON protein as well as its kinase-active form (phospho-RON) in 175 archival lung tumor FFPE (formalin fixed paraffin embedded) samples that included non-small-cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and their metastatic forms. The frequency and intensity of RON protein expression was much higher in lung tumors of neuroendocrine origin such as SCLC and in secondary tumors that metastasized to brain. In addition, the majority of the expressed RON protein was phospho-RON. We also identified 62, and 30 kDa isoforms of RON (GenBank accession numbers are JN689381 and JN689382) using RNA isolated from pooled lung cancer cell lines and RT-PCR. A majority of the NSCLC cell lines expressed a 150 kDa band that corresponded to the RON β chain and 120 kDa band in the panel of SCLC cell ...Continue Reading

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Citations

Apr 20, 2013·Journal of Carcinogenesis·Victoria M Villaflor, Ravi Salgia
Jun 26, 2013·Nature Reviews. Cancer·Hang-Ping YaoMing-Hai Wang
Jan 19, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Soundararajan KrishnaswamyNasser M Al-Daghri
Aug 6, 2015·Bioorganic & Medicinal Chemistry Letters·Franck RaeppelEric Therrien
Jul 15, 2015·Molecular Carcinogenesis·Izhar Singh BatthAddankl P Kumar
Jun 27, 2015·Bioorganic & Medicinal Chemistry Letters·Stéphane L RaeppelFranck Raeppel
May 9, 2015·Bioorganic & Medicinal Chemistry Letters·Stéphane L RaeppelEric Therrien
Jun 13, 2018·Journal of Oncology Practice·Jun Gong, Ravi Salgia
Dec 19, 2018·Veterinary Pathology·Lorella ManiscalcoRaffaella De Maria
Mar 14, 2018·ERJ Open Research·Melissa MilanGiulia Maria Stella
Jun 8, 2021·World Journal of Gastroenterology : WJG·Shao-Long ChenHang-Ping Yao

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