Differential Expression of Specific Dermatan Sulfate Domains in Renal Pathology

PloS One
J F M LensenAngelique L W M M Rops

Abstract

Dermatan sulfate (DS), also known as chondroitin sulfate (CS)-B, is a member of the linear polysaccharides called glycosaminoglycans (GAGs). The expression of CS/DS and DS proteoglycans is increased in several fibrotic renal diseases, including interstitial fibrosis, diabetic nephropathy, mesangial sclerosis and nephrosclerosis. Little, however, is known about structural alterations in DS in renal diseases. The aim of this study was to evaluate the renal expression of two different DS domains in renal transplant rejection and glomerular pathologies. DS expression was evaluated in normal renal tissue and in kidney biopsies obtained from patients with acute interstitial or vascular renal allograft rejection, patients with interstitial fibrosis and tubular atrophy (IF/TA), and from patients with focal segmental glomerulosclerosis (FSGS), membranous glomerulopathy (MGP) or systemic lupus erythematosus (SLE), using our unique specific anti-DS antibodies LKN1 and GD3A12. Expression of the 4/2,4-di-O-sulfated DS domain recognized by antibody LKN1 was decreased in the interstitium of transplant kidneys with IF/TA, which was accompanied by an increased expression of type I collagen, decorin and transforming growth factor beta (TGF-β), w...Continue Reading

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Citations

Nov 2, 2018·Biochemical Society Transactions·Johannes AlmerAndreas J Kungl
Dec 5, 2015·Glycoconjugate Journal·Khushboo Gulati, Krishna Mohan Poluri
Oct 22, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stephanie Dufek-KamperisMallory L Downie
Sep 12, 2018·Chemical Reviews·Nikos K KaramanosRenato V Iozzo

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

GraphPad Prism
GraphPad

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