Differential expression of stem cell-like proteins in normal, hyperplastic and dysplastic oral epithelium

Journal of Applied Oral Science : Revista FOB
Sarah Mohammed Mohammed Barakat, Chong Huat Siar

Abstract

The identification of stem cells (SC) remains challenging. In the human oral mucosal epithelium, these cells are believed to be in the basal layer (stem cell niche), but their exact location is unclear. The aim of this study was to examine the dysplastic oral epithelium for these SC-like proteins in order to assess their diagnostic value as biomarkers complementing the histological grading of dysplasia. Thirty oral epithelial dysplasia (OED), 25 oral lichen planus (OLP), 10 oral hyperkeratosis and 5 normal oral epithelium (OE) were immunohistochemically examined for four SC markers [integrin β1, neuron-glial-2 (NG2), notch 1 (N1) and keratin 15 (K15)]. Three of four SC markers were heterogeneously detected in all samples. K15 overexpression in the lower two-thirds of severe OED suggests an expanded SC niche. Integrin β1 distribution pattern was not measurably different between OEDs and control. NG2 was almost negative to absent in all samples examined. N1 expression was weak and highly variable in normal and dysplastic epithelium, making it an unreliable epithelial stem cell marker. Present findings suggest that these markers were unable to identify individual epithelial stem cells. Instead, subpopulations of cells, most probab...Continue Reading

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Citations

Jun 26, 2018·Oral Diseases·Suelen Teixeira LuizAline Cristina Batista Rodrigues Johann
Sep 28, 2018·Current Oncology Reports·Silvia SchmidtovaLucia Kucerova
Mar 9, 2019·Molecular and Clinical Oncology·Mohammed Amjed AlsaeghShengrong Zhu

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