PMID: 10992248Sep 19, 2000

Differential expression of the PSD-95 gene family in electrosensory neurons

The Journal of Comparative Neurology
S LeeR J Dunn


The PSD-95 family of membrane-associated guanylate kinase (MAGUK) proteins are involved in the assembly and organization of neurotransmitter receptors at excitatory synapses in the vertebrate nervous system. We have isolated partial cDNAs for five PSD-95 family members from Apteronotus leptorhynchus brain RNA using a degenerate PCR method. The amino acid sequences deduced indicate that A. leptorhynchus neurons express homologues of the mammalian PSD-93, SAP-97, and SAP-102 MAGUKs and two homologues of mammalian PSD-95. In situ hybridization experiments have been carried out to localize the cellular expression of all five MAGUK mRNAs in the central nervous system of A. leptorhynchus. In the cerebellum the expression patterns are highly similar to patterns reported for mammalian cerebellum, suggesting an evolutionary conservation of the functional roles in this gene family. Cellular levels of expression of the PSD-95 MAGUK mRNAs and the NMDAR-1 mRNA were highly correlated in neurons of the dorsal forebrain but were not correlated in neurons of the electrosensory lateral line lobe (ELL) or the cerebellum. These results suggest that the expression of PSD-95 MAGUK genes in forebrain neurons may provide mechanisms for synaptic organi...Continue Reading


Dec 1, 1991·Current Opinion in Neurobiology·W Heiligenberg
May 1, 1993·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·J Bastian
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Apr 1, 1996·Current Biology : CB·J M Anderson
Jul 8, 1996·The Journal of Comparative Neurology·G K ZupancG B Rascher
May 2, 1997·The Journal of Biological Chemistry·M TakeuchiY Takai
Jun 1, 1997·Trends in Neurosciences·M B Kennedy
Jun 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C P PontingD J Blake
Jun 1, 1997·Current Opinion in Neurobiology·H C KornauM B Kennedy
Sep 5, 1997·Science·M IrieT C Südhof
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·D Wang, L Maler
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·T TezukaT Yamamoto
Mar 11, 1999·Current Opinion in Neurobiology·M C Crair
May 20, 1999·The Journal of Comparative Neurology·L Maler, M T Hincke
Jun 11, 1999·The Journal of Biological Chemistry·A W McGee, D S Bredt
Jul 22, 1999·Annals of the New York Academy of Sciences·M Sheng, D T Pak

Related Concepts

Abnormal Degeneration
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