Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma

Science
A ar-RushdiC M Croce

Abstract

Burkitt lymphoma cells carrying either a rearranged or unrearranged c-myc oncogene were examined with the use of probes from the 5' exon and for the second and third exon of the oncogene. The results indicate that the normal c-myc gene on chromosome 8 and the 5' noncoding and 3' coding segments of the c-myc oncogene separated by the chromosomal translocation are under different transcriptional control in the lymphoma cells. Burkitt lymphoma cells carrying a translocated but unrearranged c-myc oncogene express normal c-myc transcripts. In contrast, lymphoma cells carrying a c-myc gene rearranged head to head with the immunoglobulin constant mu region gene express c-myc transcripts lacking the normal untranslated leader.

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C M CroceH Koprowski
Jun 15, 1979·Experientia·I MiyoshiJ Sato
Jan 15, 1976·International Journal of Cancer. Journal International Du Cancer·L ZechG Klein
May 5, 1972·Nature·G Manolov, Y Manolova
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K NishikuraC M Croce
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J EriksonC M Croce
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R WattG Rovera
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J EriksonC M Croce
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R TaubP Leder
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Dalla-FaveraC M Croce
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B G NeelW S Hayward

❮ Previous
Next ❯

Citations

Jan 1, 1995·Urological Research·G FournierR Lidereau
Mar 1, 1985·Journal of Clinical Immunology·K Kelly, U Siebenlist
Aug 7, 2012·Frontiers of Medicine·Jing H Wang
Apr 16, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Karina A GaloianArmen Galoyan
Jan 1, 1986·Advances in Internal Medicine·M Colb, T G Krontiris
Jan 1, 1985·Pharmacology & Therapeutics·M P Goldfarb
Jan 15, 1985·Cancer Genetics and Cytogenetics·E Pimentel
Feb 15, 1986·Cancer Genetics and Cytogenetics·D W Yandell, J B Little
Apr 15, 1986·Cancer Genetics and Cytogenetics·K OhyashikiA A Sandberg
Aug 1, 1987·Cancer Genetics and Cytogenetics·G Chenevix-Trench
Jan 1, 1987·Cancer Genetics and Cytogenetics·H R HubbellT W Dolby
Apr 1, 1988·Cancer Genetics and Cytogenetics·Y S Yan, W S Stanley
Jan 1, 1991·Cancer Genetics and Cytogenetics·T Y WangO Prakash
Dec 10, 1991·Biochimica Et Biophysica Acta·M D ReisT W Mak
Nov 1, 1984·Gene·L H Soe, P Roy-Burman
Jan 1, 1984·Nouvelle Revue Française D'hématologie·J P Lévy
Aug 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G Gaidano, A Carbone
Jul 1, 1994·European Journal of Cancer. Part B, Oral Oncology·D SaranathK Banerjee
Mar 17, 1984·Lancet·E CanaaniE Januszewicz
Jan 1, 1988·Leukemia Research·A Butturini, R P Gale
Feb 1, 2008·The New England Journal of Medicine·Carlo M Croce
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J EriksonC M Croce
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C M CroceK Nishikura
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C PeschleM G Testa
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K G WimanW S Hayward
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L PegoraroC M Croce
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·B S EmanuelC M Croce
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J EriksonC M Croce
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J C ReedR G Hoover
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M M Le BeauJ D Rowley
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K NishikuraC M Croce
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C ReedR G Hoover
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C EscotR Callahan
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A G GeiserE J Stanbridge
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T W McKeithanM O Diaz
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J LacyW C Summers

❮ Previous
Next ❯

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