PMID: 8601735Feb 1, 1996Paper

Differential expression of tissue inhibitor of metalloproteinases-2 by cutaneous squamous and basal cell carcinomas

The Journal of Investigative Dermatology
S N WagnerM Goos

Abstract

Tumor cell invasion and metastasis are considered to represent a multistep process leading to the degradation of the extracellular matrix by proteolytic enzymes. The functional activity of matrix metalloproteinases (MMPs) is controlled by tissue inhibitor of metalloproteinases-2 (TIMP-2), which has been shown to inhibit tumor cell invasion and metastasis in vitro and in vivo. To assess the role of TIMP-2 in skin-derived epithelial tumors, we have analyzed the expression of TIMP-2 mRNA in primary tissue samples from human cutaneous basal (BCC) and squamous cell carcinoma (SCC) for a correlation with their different invasive and metastatic potential. Comparative quantitative analysis of TIMP-2 mRNA levels by Northern blot hybridization demonstrated significantly higher TIMP-2 tissue levels in BCC than in SCC, indicating an inverse correlation between TIMP-2 expression and the metastatic capacity of these tumors in vivo. By in situ hybridization, tumor stromal cells were identified as the principal source of TIMP-2 mRNA in both BCC and SCC. A comparable distribution has been reported previously for several matrix metalloproteinases in cutaneous BCC and SCC, indicating co-localization of metalloproteinases with their respective inh...Continue Reading

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Citations

Feb 5, 1998·Experimental Dermatology·V M Kähäri, U Saarialho-Kere
May 9, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K AirolaU K Saarialho-Kere
Sep 2, 2020·Experimental Dermatology·Pilvi RiihiläVeli-Matti Kähäri
Apr 19, 2003·Experimental Dermatology·E Kerkelä, U Saarialho-Kere
Apr 29, 1999·Annals of Medicine·V M Kähäri, U Saarialho-Kere
Dec 29, 2020·Cancer Management and Research·Chenmeiyi WangZhibiao Wang
Jan 9, 2001·The Journal of Investigative Dermatology. Symposium Proceedings·S L Raza, L A Cornelius

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