Differential expression of TOX by skin-infiltrating T cells in Sézary syndrome and erythrodermic dermatitis

Journal of Cutaneous Pathology
Stephanie E BoonkR Willemze

Abstract

The histopathologic differentiation between Sézary syndrome (SS) and erythrodermic dermatitis may be extremely difficult. In this immunohistochemical study, it was investigated if thymocyte selection-associated high mobility group box protein (TOX) and C-MYC can be used as additional diagnostic markers to differentiate between SS and erythrodermic dermatitis. Paraffin-embedded skin biopsies from 15 SS patients and 17 erythrodermic dermatitis patients were stained and scored for TOX or C-MYC expression. Strong nuclear staining for TOX in more than 50% of skin-infiltrating T cells was observed in 13 of 15 (87%) SS cases, whereas erythrodermic dermatitis cases showed weak nuclear staining in 11-50% (median: 25%) of the T cells; strong nuclear staining as found in SS was never observed in erythrodermic dermatitis. No significant differences in C-MYC expression between SS and erythrodermic dermatitis were found. In most patients of both groups, percentages of C-MYC positive-cells varied between less than 10 and 25% of skin-infiltrating T cells. Our results suggest that strong expression of TOX in more than 50% of skin-infiltrating T cells in erythrodermic skin is a useful marker in the differentiation between SS and erythrodermic de...Continue Reading

References

Feb 19, 2002·Nature Immunology·Beverley WilkinsonJonathan Kaye
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Apr 17, 2008·Cancer Research·Maarten H VermeerCornelis P Tensen
Feb 5, 2010·The Journal of Investigative Dermatology·Elodie LaharanneJean-Philippe Merlio
Jun 19, 2010·The American Journal of Dermatopathology·Caroline Ram-WolffNicolas Ortonne
Jan 3, 2012·Current Opinion in Immunology·Parinaz AliahmadJonathan Kaye
Mar 2, 2012·The Journal of Investigative Dermatology·Yaohua ZhangYouwen Zhou
Apr 21, 2012·Journal of Cutaneous Pathology·Meghali GoswamiXiao Ni
Dec 19, 2012·Archives of Dermatology·Fatma CetinözmanRein Willemze
Dec 7, 2013·The Journal of Investigative Dermatology·Laura Y McGirtChristine M Eischen
Mar 8, 2014·The British Journal of Dermatology·F ÇetinözmanR Willemze
Sep 14, 2014·Archives of Dermatological Research·Sohshi MorimuraShinichi Sato

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Citations

Mar 15, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Rudolf Stadler
Mar 15, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jan P NicolayCyrill Géraud
May 18, 2016·Archives of Dermatological Research·Anne M R SchraderRein Willemze
Oct 25, 2016·The Journal of Investigative Dermatology·Ahmed HaiderMarkus Möbs
Oct 6, 2016·Current Hematologic Malignancy Reports·Rebecca KohnkenAnjali Mishra
Nov 9, 2016·Disease Markers·Alexandra IonDaniel Boda
Jun 5, 2018·Experimental Dermatology·Rudolf Stadler, René Stranzenbach
Jun 27, 2019·Journal of Cutaneous Pathology·Christina Mitteldorf, Werner Kempf
Aug 19, 2016·The British Journal of Dermatology·W Kempf
Nov 5, 2019·Archives of Dermatological Research·Jingkai XuYaohua Zhang

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