Differential expression of transcription factors in the accumbens of an animal model of ADHD

Neuroreport
M PapaA G Sadile

Abstract

Transcription factors have been used as neuronal markers in the nucleus accumbens (ACB) of male juvenile spontaneously hypertensive rats (SHR), an animal model of attention-deficit hyperactivity disorder (ADHD), to trace putative neural substrates. In SHR, immunocytochemistry and PC-assisted image analysis showed lower expression of pan-fos, c-fos, zif/268 in the shell, and the c-fos and zif/268 in the core, with an increased level of Jun-B in the core. The differential lower basal expression of transcription factors in the ACB of an animal model of ADHD implies a reduced number of modules and might represent a neural substrate of the attention deficits seen in SHR and children with ADHD at low motivational levels.

References

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Citations

Nov 20, 2003·Neuroscience and Biobehavioral Reviews·Walter AdrianiGiovanni Laviola
Feb 3, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Catharine A WinstanleyTrevor W Robbins
Sep 13, 2008·Developmental Neuropsychology·Chris StintonYannick Courbois
Jul 19, 2005·Behavioral and Brain Functions : BBF·Vivienne A RussellEspen Borgå Johansen
Nov 6, 2007·Journal of Neuroscience Methods·Vivienne Ann Russell
Feb 6, 2007·Journal of Neuroscience Methods·Vivienne Ann Russell
Mar 1, 2006·Clinical Psychology Review·Catharine A WinstanleyTrevor W Robbins

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