Differential expression of transforming growth factor-beta receptors in a rabbit zone II flexor tendon wound healing model

Plastic and Reconstructive Surgery
M NgoJ Chang

Abstract

Flexor tendon repair in zone II is complicated by adhesions that impair normal postoperative gliding. Transforming growth factor-beta (TGF-beta) is a family of growth factors that has been implicated in scar formation. The TGF-beta family of proteins binds to three distinct classes of membrane receptors, termed RI, RII, and RIII. In this study, we analyzed the temporal and spatial distribution of TGF-beta receptor isoforms (RI, RII, and RIII) in a rabbit zone II flexor tendon wound healing model.Twenty-eight adult New Zealand White rabbit forepaws underwent isolation of the middle digit flexor digitorum profundus tendon in zone II. The tendons underwent transection in zone II and immediate repair. The tendons were harvested at increasing time points: 1, 3, 7, 14, 28, and 56 days postoperatively (n = 4 at each time point). The control flexor tendons were harvested without transection and repair (n = 4). Immunohistochemical analysis was used to detect the expression patterns for TGF-beta receptors RI, RII, and RIII. Immunohistochemical staining of the transected and repaired tendons demonstrated up-regulation of TGF-beta RI, RII, and RIII protein levels. TGF-beta receptor production in the experimental group (transection and repa...Continue Reading

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Citations

Aug 21, 2013·Differentiation; Research in Biological Diversity·Yulia ShwartzElazar Zelzer
Jun 1, 2005·Foot and Ankle Clinics·Pankaj Sharma, Nicola Maffulli
Mar 27, 2004·The Journal of Hand Surgery·Andrew Y ZhangJames Chang
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