Differential expression of vascular endothelial growth factor in human fetal skeletal site-specific tissues: Mandible versus femur

Acta histochemica
M MariniE Sgambati

Abstract

Vascular endothelial growth factor (VEGF) is a well-known mediator that signals through pathways in angiogenesis and osteogenesis. Angiogenesis and bone formation are coupled during either skeletal development or bone remodeling and repair occurring in postnatal life. In this study, we examined for the first time the expression of VEGF in human fetal mandibular and femoral bone in comparison with the respective adult tissues. Similarly to other craniofacial bones, but at variance with the axial and appendicular skeleton, during development mandible does not arise from mesoderm but neural crest cells of the neuroectoderm germ layer, and undergoes intramembranous instead of endochondral ossification. By quantitative real-time PCR technique, we could show that VEGF gene expression levels were significantly higher in fetal than in adult samples, especially in femoral tissue. Western blotting analysis confirmed higher protein expression of VEGF in the fetal femur respect to the mandible. Moreover, immunohistochemistry revealed that in both fetal tissues VEGF expression was mainly localized in pre- and osteoblasts. Differential expression of VEGF in femoral and mandibular bone tissues could be related to their different structure, fu...Continue Reading

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Citations

Feb 27, 2016·Journal of Dental Research·S MacariT A Silva
Jan 13, 2019·Journal of Molecular Histology·Xue YangXiongcheng Xu
Jan 20, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yasuyuki FujiiI-Ping Chen
Jun 30, 2021·Life Sciences·Renata Mendonça MoraesAna Lia Anbinder

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