PMID: 8595131Nov 1, 1995Paper

Differential expression of VLA beta 1 (CD29) on monocytes from patients with endometriosis

American Journal of Reproductive Immunology : AJRI
H GebelW P Dmowski

Abstract

Previous studies have established that in vitro proliferation of endometrial cells is enhanced by peripheral blood monocytes (PBM) and suppressed by peritoneal macrophages (PM) from patients with endometriosis but only suppressed by PBM and PM obtained from normal subjects. The functional activity of PBM and PM is influenced by the engagement of numerous cell surface receptors with their respective physiological ligands. In this study, PBM and PM from fertile women (Group 1), women with unexplained infertility (Group 2), and women with limited (Group 3) or severe (Group 4) endometriosis were isolated in order to analyze these cells for the expression of CD54, CD58 and HLA-DR (immunoglobulin supergene antigens) CD18 and CD29 (integrins) and CD44 (an addresin). These cell surface antigens are involved in monocyte/macrophage trafficking, activation, signal transduction and/or adhesion. No differences were detected in the percentage of PBM expressing CD18, CD44, CD54, CD58, or HLA-DR among the four groups of subjects. Furthermore, the density of these antigens expressed on PBM was identical in patients and control subjects. In contrast, the percentage of PBM expressing CD29 (also known as VLA beta 1) and the density of CD29 express...Continue Reading

References

Dec 1, 1992·The Journal of Experimental Medicine·E A FreyS D Wright
Jan 1, 1992·Advances in Experimental Medicine and Biology·P D KassnerM E Hemler
Aug 2, 1990·Nature·T A Springer
Jul 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Mar 1, 1993·Immunology Today·H W Ziegler-Heitbrock, R J Ulevitch
Mar 1, 1993·American Journal of Reproductive Immunology : AJRI·H M GebelW P Dmowski

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Citations

May 2, 2016·The Cochrane Database of Systematic Reviews·Vicki NisenblatM Louise Hull

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