Differential expression of ZFX gene in gastric cancer.

Journal of Biosciences
Parvaneh NikpourShaghayegh Haghjooy-Javanmard

Abstract

Gastric cancer accounts for 8% of the total cancer cases and 10% of total cancer deaths worldwide. In Iran, gastric cancer is the leading cause of national cancer-related mortality. Most human cancers show substantial heterogeneity. The cancer stem cell (CSC) hypothesis has been proposed to reconcile this heterogeneity. ZFX encodes a member of the krueppel C2H2-type zinc-finger protein family that is required as a transcriptional regulator for self-renewal of stem cells. A total of 30 paired tissue gastric samples were examined for ZFX gene expression by quantitative real-time RT-PCR. Although the relative expression of the gene was significantly high in 47% of the examined tumour tissues, its expression was low in the others (53%). There was a statistically significant association between the ZFX gene expression and different tumour types and grades. This is the first report that shows ZFX was differentially expressed in gastric cancer. Of note, it was overexpressed in diffused-type and grade III gastric tumoural tissues. Due to this, ZFX may have the potential to be used as a target for therapeutic interventions.

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Citations

Jan 23, 2014·Cancer Chemotherapy and Pharmacology·Hongjian YangZhiqiang Ling
Jun 21, 2014·Advanced Biomedical Research·Elaheh Emadi-AndaniAli Bidmeshkipour
Apr 29, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hongzhi MaJugao Fang
Nov 1, 2016·Acta Biochimica Et Biophysica Sinica·Jie WuXiuyan Zhang
Aug 5, 2017·Future Oncology·Raheleh RoudiZahra Madjd
Dec 12, 2012·Nature Structural & Molecular Biology·David GokhmanEran Meshorer
May 2, 2017·Briefings in Functional Genomics·Modjtaba Emadi-BaygiParvaneh Nikpour
Nov 13, 2020·Clinical and Experimental Gastroenterology·Khadijeh Kalan FarmanfarmaHamid Salehiniya

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