Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments.

Journal of the American Society of Nephrology : JASN
Yumiko Kiuchi-SaishinS Tsukita

Abstract

As the first step in understanding the physiologic functions of claudins (tight junction integral membrane proteins) in nephrons, the expression of claudin-1 to -16 in mouse kidneys was examined by Northern blotting. Among these claudins, only claudin-6, -9, -13, and -14 were not detectable. Claudin-5 and -15 were detected only in endothelial cells. Polyclonal antibodies specific for claudin-7 and -12 were not available. Therefore, the distributions of claudin-1, -2, -3, -4, -8, -10, -11, and -16 in nephron segments were examined with immunofluorescence microscopy. For identification of individual segments, antibodies specific for segment markers were used. Immunofluorescence microscopic analyses of serial frozen sections of mouse kidneys with polyclonal antibodies for claudins and segment markers revealed that claudins demonstrated very complicated, segment-specific, expression patterns in nephrons, i.e., claudin-1 and -2 in Bowman's capsule, claudin-2, -10, and -11 in the proximal tubule, claudin-2 in the thin descending limb of Henle, claudin-3, -4, and -8 in the thin ascending limb of Henle, claudin-3, -10, -11, and -16 in the thick ascending limb of Henle, claudin-3 and -8 in the distal tubule, and claudin-3, -4, and -8 in...Continue Reading

References

Aug 1, 1973·The Journal of Cell Biology·P Claude, D A Goodenough
Oct 1, 1974·Kidney International·M M Schwartz, M A Venkatachalam
Jan 1, 1974·International Review of Cytology·L A Staehelin
Sep 1, 1973·The American Journal of Physiology·M D LutzM B Burg
Oct 1, 1971·The American Journal of Physiology·E L Boulpaep, J F Seely
Dec 1, 1993·The Journal of Cell Biology·M FuruseS Tsukita
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·D A Goodenough
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·K MoritaS Tsukita
Jun 17, 1999·Trends in Cell Biology·S Tsukita, M Furuse
Apr 4, 2000·The Journal of Cell Biology·S Tsukita, M Furuse
Apr 7, 2000·Journal of the American Society of Nephrology : JASN·Peter Agre
Apr 3, 2001·Nature Reviews. Molecular Cell Biology·S TsukitaM Itoh
May 1, 1963·The Journal of Cell Biology·M G FARQUHAR, G E PALADE

❮ Previous
Next ❯

Citations

Apr 3, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mallory L Downie, R Todd Alexander
Dec 31, 2002·Journal of the American Society of Nephrology : JASN·Martin Konrad, Stefanie Weber
Feb 6, 2017·The Journal of Biological Chemistry·Anindit MukherjeeRebecca P Hughey
Oct 16, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Zsuzsanna NémethZsuzsa Schaff
Sep 17, 2002·Current Opinion in Cell Biology·Shoichiro Tsukita, Mikio Furuse
Dec 12, 2002·Progress in Biophysics and Molecular Biology·L González-MariscalB E Jaramillo
Apr 23, 2003·Biochemical and Biophysical Research Communications·P FlorianA H Gitter
Mar 5, 2003·The Journal of Biological Chemistry·Alan S L YuEveline E Schneeberger
May 3, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hiroki FujitaNorimasa Sawada
Sep 5, 2017·Annals of the New York Academy of Sciences·Hiroo TanakaSachiko Tsukita
Jul 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Hiroshi TamagawaHiroshi Kiyono
Feb 7, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jouko J LaurilaTero I Ala-Kokko
Aug 16, 2003·Current Opinion in Nephrology and Hypertension·Alan S L Yu
Apr 17, 2009·Journal of Virology·Guruprasad R MedigeshiJay A Nelson
Apr 28, 2004·The International Journal of Biochemistry & Cell Biology·Nicole S Harhaj, David A Antonetti
Dec 31, 2003·Hearing Research·Shin-iciro KitajiriShoichiro Tsukita
Apr 8, 2004·American Journal of Physiology. Renal Physiology·Prasad AcharyaGerard Apodaca
Jun 17, 2021·Scientific Reports·Masayuki WatanabeHideki Chiba
Jan 15, 2004·American Journal of Physiology. Renal Physiology·Wing Y LiAlan S L Yu
May 21, 2004·American Journal of Physiology. Cell Physiology·Eveline E Schneeberger, Robert D Lynch
May 26, 2004·Journal of Cell Science·Kursad Turksen, Tammy-Claire Troy
Dec 1, 2004·The Journal of Biological Chemistry·Joshua H LipschutzDaniel F Balkovetz
Jun 22, 2021·American Journal of Physiology. Renal Physiology·Caroline Prot-BertoyeHenrik Dimke
Jan 14, 2021·American Journal of Physiology. Cell Physiology·Shaista AnwerKatalin Szászi
Jul 23, 2004·Physiological Reviews·Gianfranco Bazzoni, Elisabetta Dejana
Sep 15, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Atsushi HashizumeYohki Hieda
Sep 24, 2004·Experimental Cell Research·Tamotsu SomaNorimasa Sawada
Aug 21, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C Graham, N L Simmons
Sep 24, 2004·Physiological Reviews·M CereijidoL Shoshani
Mar 8, 2005·Cancer Immunology, Immunotherapy : CII·Sonja OffnerBirgit Kohleisen
Nov 20, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xing-He WengAndrea Quaroni
Nov 24, 2004·Cell and Tissue Research·C Adriana Mendoza-RodríguezMarco Cerbón
Dec 9, 2004·Pediatric Research·Maha HaddadMichel Baum
Mar 3, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marcello Camici

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Renal Physiology
Wing Y LiAlan S L Yu
Annual Review of Physiology
Jianghui HouAlan S L Yu
American Journal of Physiology. Renal Physiology
A H EnckA S Yu
Developmental Dynamics : an Official Publication of the American Association of Anatomists
Atsushi HashizumeYohki Hieda
© 2022 Meta ULC. All rights reserved