Differential expression profile and genetic variants of microRNAs sequences in breast cancer patients.

PloS One
Ali A AlshatwiAbdulaziz A Alsaif

Abstract

The technology available for cancer diagnosis and prognosis is not yet satisfactory at the molecular level, and requires further improvements. Micro RNAs (miRNAs) have been recently reported as useful biomarkers in diseases including cancer. We performed a miRNA expression profiling study using peripheral blood from breast cancer patients to detect and identify characteristic patterns. A total of 100 breast cancer patients and 89 healthy patients were recruited for miRNA genotyping and expression profiling. We found that hs-miR-196a2 in premenopausal patients, and hs-miR-499, hs-miR-146a and hs-miR-196a2 in postmenopausal patients, may discriminate breast cancer patients from healthy individuals. In addition, we found a significant association between two microRNA polymorphisms (hs-miR-196a2 and hs-miR-499) and breast cancer risk. However, no significant association between the hs-miR-146a gene and breast cancer risk was found. In summary, the study demonstrates that peripheral blood miRNAs and their expression and genotypic profiles can be developed as biomarkers for early diagnosis and prognosis of breast cancer.

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Citations

Nov 22, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hongzhi SunWei Wang
Aug 29, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qiao-Hui ChenBei Zhang
Mar 13, 2014·Pediatric Research·Angela Gutierrez-CaminoAfrica Garcia-Orad
Mar 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhengjun KangChaohui Gu
Jan 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bangshun HeShukui Wang
May 27, 2015·Acta Biochimica Et Biophysica Sinica·Xiaoyan LiuPeihua Ni
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Jan 16, 2019·International Journal of Molecular Sciences·Milad BastamiZiba Nariman-Saleh-Fam
Sep 25, 2020·AIMS Public Health·Wedad Saeed AlqahtaniBassam Ahmed Almutlaq
Oct 17, 2019·International Journal of Molecular Sciences·Milad BastamiZiba Nariman-Saleh-Fam
Feb 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Sheng-Gao JiangShan-Liang Zhong

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Methods Mentioned

BETA
PCR
genotyping
electrophoresis
PCRs

Software Mentioned

SDS
SPSS

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