Differential Features between Chronic Skin Inflammatory Diseases Revealed in Skin-Humanized Psoriasis and Atopic Dermatitis Mouse Models

The Journal of Investigative Dermatology
Marta CarreteroMarcela Del Río

Abstract

Psoriasis and atopic dermatitis are chronic and relapsing inflammatory diseases of the skin affecting a large number of patients worldwide. Psoriasis is characterized by a T helper type 1 and/or T helper type 17 immunological response, whereas acute atopic dermatitis lesions exhibit T helper type 2-dominant inflammation. Current single gene and signaling pathways-based models of inflammatory skin diseases are incomplete. Previous work allowed us to model psoriasis in skin-humanized mice through proper combinations of inflammatory cell components and disruption of barrier function. Herein, we describe and characterize an animal model for atopic dermatitis using similar bioengineered-based approaches, by intradermal injection of human T helper type 2 lymphocytes in regenerated human skin after partial removal of stratum corneum. In this work, we have extensively compared this model with the previous and an improved version of the psoriasis model, in which T helper type 1 and/or T helper type 17 lymphocytes replace exogenous cytokines. Comparative expression analyses revealed marked differences in specific epidermal proliferation and differentiation markers and immune-related molecules, including antimicrobial peptides. Likewise, ...Continue Reading

Citations

Jan 12, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jingling ZhaoSeok Jong Hong
Oct 5, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K MalikE Guttman-Yassky
Jun 2, 2020·Immunology and Cell Biology·Sara Guerrero-AspizuaMarcela Del Río
Feb 11, 2021·Journal of Clinical Medicine·Justin ChoiMadan M Kwatra
Oct 14, 2019·The Journal of Allergy and Clinical Immunology·Amos GilharRalf Paus
Dec 18, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Irene Dolz-PérezMaría J Vicent
Dec 29, 2020·Experimental Dermatology·Amos GilharRalf Paus
Jul 3, 2021·International Journal of Molecular Sciences·Andrés MonteroDiego Velasco

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