Differential Features of Culprit Intracranial Atherosclerotic Lesions: A Whole-Brain Vessel Wall Imaging Study in Patients With Acute Ischemic Stroke

Journal of the American Heart Association
Fang WuWISP Investigators

Abstract

Intracranial atherosclerotic disease tends to affect multiple arterial segments. Using whole-brain vessel wall imaging, we sought to study the differences in plaque features among various types of plaques in patients with a recent unilateral anterior circulation ischemic stroke. Sixty-one patients with unilateral anterior circulation ischemic stroke were referred to undergo whole-brain vessel wall imaging (before and after contrast) within 1 month of symptom onset for intracranial atherosclerotic disease evaluations. Each plaque was classified as a culprit, probably culprit, or nonculprit lesion, according to its likelihood of causing the stroke. The associations between plaque features (thickening pattern, plaque-wall contrast ratio, high signal on T1-weighted images, plaque contrast enhancement ratio, enhancement grade, and enhancement pattern) and culprit lesions were estimated using mixed multivariable logistic regression after adjustment for maximum wall thickness. In 52 patients without motion corruption in whole-brain vessel wall imaging, a total of 178 intracranial plaques in the anterior circulation were identified, including 52 culprit lesions (29.2%), 51 probably culprit lesions (28.7%), and 75 nonculprit lesions (42...Continue Reading

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Citations

Nov 1, 2018·Journal of Neuroscience Research·Cui YangYang Xiang
Aug 31, 2020·Journal of Magnetic Resonance Imaging : JMRI·Xia TianChengcheng Zhu
Oct 2, 2020·Stroke; a Journal of Cerebral Circulation·Rami FakihEdgar A Samaniego
Sep 29, 2019·AJNR. American Journal of Neuroradiology·J W Song
May 12, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jae W SongZhaoyang Fan
Dec 29, 2020·Stroke; a Journal of Cerebral Circulation·Jae W SongSteven R Messé
Nov 14, 2020·Current Opinion in Rheumatology·Serdar ArslanOsman Kizilkilic
Mar 27, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zhehao HuZhaoyang Fan
Aug 19, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Daniel MontesJavier Romero

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Methods Mentioned

BETA
imaging technique

Software Mentioned

R
Osirix MD
SPSS

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