PMID: 5909697Mar 1, 1966

Differential ferrioxamine test in idiopathic haemochromatosis and transfusional haemosiderosis

Journal of Clinical Pathology
J FieldingG M Brunström

Abstract

The differential ferrioxamine test measures the amount of body iron as ferrioxamine (Fv) chelated by a standard dose of desferrioxamine.Five patients with untreated, uncomplicated idiopathic haemochromatosis and one with transfusion haemosiderosis gave Fv in the range 1,948 to 2,462 mug./kg. (normal 110 to 500). One case of transfusion haemochromatosis with haemolytic anaemia and renal failure gave an Fv value of 8,019 mug./kg. Four patients with idiopathic haemochromatosis after therapeutic venesection gave Fv values of 212 to 885 mug./kg. One relative with a value for Fv of 776 mug./kg. was shown to have early cirrhosis by liver biopsy. Serial Fv measurement after venesection in this patient provided a preliminary assessment of the relationship between Fv values and available iron stores up to about 2,000 mg. iron. This relationship applies only when red cell survival is normal. Approximate figures for the range of available storage iron in 31 healthy men are deduced, namely, 200 mg. to 1,000 mg. (3 to 14 mg./kg.). The test should prove useful in the diagnosis of iron overload, in the screening of relatives for early haemochromatosis, and in the management of iron storage diseases.

References

Jun 1, 1957·Clinica Chimica Acta; International Journal of Clinical Chemistry·W N RAMSAY
Jul 6, 1961·The New England Journal of Medicine·W G FREYF G EBAUGH
Jul 1, 1964·Journal of Clinical Pathology·J Fielding, M BRUNSTROEM
Jan 1, 1965·Journal of Clinical Pathology·J Fielding
May 1, 1960·Journal of Clinical Pathology·D KOK, F WILD
Jul 1, 1962·The Journal of Pathology and Bacteriology·P J SCHEUERA R MUIR
Jun 1, 1952·The Journal of Clinical Investigation·D HASKINSC A Finch
Dec 15, 1962·British Medical Journal·R M BannermanD L Williams

Citations

Nov 1, 1967·British Journal of Haematology·C Karabus, J Fielding
Jan 1, 1968·British Journal of Haematology·E N Wardle, M C Israëls
Dec 1, 1969·British Journal of Haematology·A A WapnickT H Bothwell
Jun 1, 1977·Archives of Disease in Childhood·B Modell
Feb 25, 1967·British Medical Journal
Jul 1, 1966·Journal of Clinical Pathology·M C O'ShaughnessyJ Fielding
Aug 1, 1979·The Journal of Pediatrics·J M GertnerM Genel
Sep 1, 1983·Journal of Religion and Health·S Hunt-Meeks
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·G D McLarenR W Kellermeyer
Oct 1, 1969·Acta Odontologica Scandinavica·F Nordh

Related Concepts

Microangiopathic Hemolytic Anemia
Biopsy
Blood Chemical Analysis
Bloodletting
Desferal
Intravenous Glucose Tolerance Test
Hereditary Hemochromatosis
Hemosiderosis
Iron Chelating Agents
Liver

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.