Differential functional response in the posteromedial cortices and hippocampus to stimulus repetition during successful memory encoding.

Human Brain Mapping
Patrizia VanniniReisa Sperling

Abstract

The reduction of neural activity in response to repeated stimuli, repetition suppression, is one of the most robust experience-related cortical dynamics known to cognitive neuroscience. Functional magnetic resonance imaging (fMRI) studies during episodic memory encoding have demonstrated repetition suppression in the hippocampus and this reduction has been linked to successful memory formation. An emerging body of functional imaging evidence suggests that the posteromedial cortex, in addition to the medial temporal lobes, may have a pivotal role in successful episodic memory. This area typically deactivates during initial memory encoding, but its functional changes in response to repetitive encoding remain poorly specified. Here, we investigate the repetition-related changes in the posteromedial cortex as well as the hippocampus while the participants underwent an fMRI experiment involving repetitive encoding of face-name pairs. During the first encoding trial of face-name pairs, significant activation in the hippocampus was observed. The second and third encoding trials demonstrated a repetition suppression effect in the hippocampus, indicated by a stepwise decrease of activation. In contrast, the posteromedial cortex demonstr...Continue Reading

References

Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·R Desimone
Mar 10, 1998·Neuron·D L Schacter, R L Buckner
Jun 23, 1998·Current Opinion in Neurobiology·C L Wiggs, A Martin
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·A IshaiJ V Haxby
May 29, 2000·Trends in Cognitive Sciences·J V HaxbyM I Gobbini
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Mar 17, 2001·Nature Reviews. Neuroscience·H Eichenbaum
Oct 10, 2001·Current Biology : CB·L J Otten, M D Rugg
Dec 1, 2001·Current Biology : CB·A D Wagner, L Davachi
Sep 10, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael D RuggRichard N A Henson
Dec 13, 2002·Brain : a Journal of Neurology·S M DaselaarC Jonker
Dec 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·R A SperlingM S Albert
Feb 26, 2003·Neurobiology of Aging·Georg GrönMatthias W Riepe
May 6, 2003·Journal of Cognitive Neuroscience·Kristen A McKiernanJeffrey R Binder
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Mar 5, 2004·Neuropsychologia·Sterling C JohnsonRichard J Caselli
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alumit IshaiLeslie G Ungerleider
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin J Shannon, Randy L Buckner
Dec 17, 2004·Journal of Cognitive Neuroscience·Michael D Greicius, Vinod Menon
Feb 12, 2005·Brain : a Journal of Neurology·Alexandra GolbyJohn Gabrieli
Nov 5, 2005·NeuroImage·Kristen A McKiernanJeffrey R Binder
Nov 16, 2005·Nature Neuroscience·Yun-Ching KaoJohn D E Gabrieli
Nov 22, 2005·Neurobiology of Aging·Erin Rand-GiovannettiReisa A Sperling
Dec 3, 2005·Trends in Cognitive Sciences·Kalanit Grill-SpectorAlex Martin
Jun 30, 2006·Neuropsychologia·Eva SvobodaBrian Levine
Jul 25, 2006·Journal of Cognitive Neuroscience·Eleni OrfanidouMatthew H Davis
Jan 20, 2007·Science·Malia F MasonC Neil Macrae
Jun 1, 2007·Journal of Cognitive Neuroscience·Jonas PerssonPatricia A Reuter-Lorenz
Sep 14, 2007·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Sterling C JohnsonCatherine Myers
Feb 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Saul L MillerReisa A Sperling
Apr 2, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Maija PihlajamäkiReisa A Sperling
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Jun 25, 2008·Social Cognitive and Affective Neuroscience·Marcia K JohnsonSusan Nolen-Hoeksema
Jul 22, 2008·Nature Reviews. Neuroscience·Roberto CabezaMorris Moscovitch

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Citations

Jan 19, 2016·Neuron·Elizabeth V GoldfarbElizabeth A Phelps
Apr 23, 2014·Hippocampus·Nico A W KremersNikolai Axmacher
May 6, 2015·Cognitive, Affective & Behavioral Neuroscience·Nancy A DennisAmy A Overman
Nov 18, 2014·Biomarkers in Medicine·Elizabeth G KehoeArun L W Bokde
Jul 6, 2016·Brain and Language·A LlorensC Liégeois-Chauvel
Jun 18, 2016·Journal of Cognitive Neuroscience·Niv ReggevAnat Maril
Dec 29, 2016·Human Brain Mapping·Vesna PrčkovskaJorge Sepulcre
Jul 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Svenja Brodt, Steffen Gais
Jun 29, 2017·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Sarah M JurickMark W Bondi
Jun 5, 2021·Frontiers in Neural Circuits·Jiahe GuoXuejun Yang
May 29, 2021·Neurobiology of Learning and Memory·Darya Frank, Alex Kafkas

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