Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization

Neoplasma
Z PanR Shao

Abstract

Cervical cancer is one of the most common gynecological cancers worldwide. Over the past decade, much progress has been made in understanding the genetic changes associated with the development and progression of cervical cancer. However, the precise mechanisms of cervical carcinogenesis in Uigur women remain unclear. To screen differential gene expression in squamous cell carcinoma (SCC) of the cervix in Uigur women, suppressive subtractive hybridization (SSH) was performed on the cervical squamous cell carcinoma and corresponding normal cervical tissues of a Uigur patient. Thus we were be able to find the genes that are related with cervical tumors of Uigur women. A total of 300 samples were subject to DNA sequencing analysis and 46 genes were found to express differentially in tumors compared with normal tissues. Of the 46 genes, 24 genes were up-regulated whereas 22 genes were down-regulated in cervical tumors. The expression profiles of 5 of the 46 genes were further confirmed in 15 other Uigur patients by semi-quantitative reverse-transcription polymerase chain reaction. Our results revealed that ACADVL, CEBPB, IFITM1 and DNAJC9 are involved in cervical carcinogenesis.

Citations

May 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dawei LiKeping Xie
Aug 12, 2015·Cancer Letters·Fang YuMarie C Lin
Aug 20, 2016·Infectious Agents and Cancer·Hongchang HeRenfu Shao
Oct 21, 2017·Cancer Cell International·Weinan ZhengRenfu Shao
Aug 3, 2016·Medical Sciences : Open Access Journal·Alireza TorabiChun Xu
Sep 10, 2014·The International Journal of Biological Markers·Qiangqiang ZuoRenfu Shao
Aug 8, 2020·Molecular Biology Reports·Jie JiMing-Bing Xiao

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